Kanabinoidy neovlivňovaly senzitizaci k metamfetaminu u potkanů

Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F05%3A00013829" target="_blank" >RIV/00216224:14110/05:00013829 - isvavai.cz</a>
Výsledek na webu
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DOI - Digital Object Identifier
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Jazyk výsledku
angličtina
Název v původním jazyce
Cannabinoids did not affect sensitization to methamphetamine in rats
Popis výsledku v původním jazyce
Obtained data clearly demonstrated that as previously in mice a repeated administration of methamphetamine elicited behavioural sensitization to its stimulatory effects in rats. However, we were not able to provoke cross-sensitization by repeated application of cannabinoid CB1 receptor agonist methanandamide and similarly, we did not demonstrate suppression of the cross-sensitization in rats that were repeatedly given combined pre-treatment of cannabinoid CB1 receptor antagonist AM 251 and methamphetamine as it was demonstrated in research carried out in mice.
Název v anglickém jazyce
Cannabinoids did not affect sensitization to methamphetamine in rats
Popis výsledku anglicky
Obtained data clearly demonstrated that as previously in mice a repeated administration of methamphetamine elicited behavioural sensitization to its stimulatory effects in rats. However, we were not able to provoke cross-sensitization by repeated application of cannabinoid CB1 receptor agonist methanandamide and similarly, we did not demonstrate suppression of the cross-sensitization in rats that were repeatedly given combined pre-treatment of cannabinoid CB1 receptor antagonist AM 251 and methamphetamine as it was demonstrated in research carried out in mice.

Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FR - Farmakologie a lékárnická chemie
OECD FORD obor
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Rok uplatnění
2005
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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