Glutamát a behaviorální sensitizace: přehled experimentálních studií

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F04%3A00010762" target="_blank" >RIV/00216224:14110/04:00010762 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Glutamate and behavioural sensitization: review of the experimental studies

Popis výsledku v původním jazyce

Repeated drug administration leading to a progressively enhanced response persisting even after long periods of withdrawal, a phenomenon termed sensitization, is suggested to be involved in the development and maintenance of drug addiction and also relapse to drug-taking behaviour in weaned addicts. Thus, sensitization is known to be induced by agents acting directly or indirectly on the dopaminergic VTA-accumbens projection and development of sensitization is reported to require transient increase in glutamatergic neurons from the prefrontal cortex to the ventral tegmental area (VTA) leading to activation of the mentioned dopaminergic pathway (Everitt and Wolf, 2002). This suggestion is supported by studies in which the development of behavioural sensitization to cocaine, amphetamine, methamphetamine and morphine as one of forms of neuronal plasticity was prevented by noncompetitive (dizocilpine, memantine) and competitive (CGS 1975) glutamate NMDA receptor antagonists (e.g. Karler et

Název v anglickém jazyce

Glutamate and behavioural sensitization: review of the experimental studies

Popis výsledku anglicky

Repeated drug administration leading to a progressively enhanced response persisting even after long periods of withdrawal, a phenomenon termed sensitization, is suggested to be involved in the development and maintenance of drug addiction and also relapse to drug-taking behaviour in weaned addicts. Thus, sensitization is known to be induced by agents acting directly or indirectly on the dopaminergic VTA-accumbens projection and development of sensitization is reported to require transient increase in glutamatergic neurons from the prefrontal cortex to the ventral tegmental area (VTA) leading to activation of the mentioned dopaminergic pathway (Everitt and Wolf, 2002). This suggestion is supported by studies in which the development of behavioural sensitization to cocaine, amphetamine, methamphetamine and morphine as one of forms of neuronal plasticity was prevented by noncompetitive (dizocilpine, memantine) and competitive (CGS 1975) glutamate NMDA receptor antagonists (e.g. Karler et

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2004

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Psychiatrie

ISSN

1211-7579

e-ISSN

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Svazek periodika

8

Číslo periodika v rámci svazku

Suppl.4

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

1

Strana od-do

47-47

Kód UT WoS článku

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EID výsledku v databázi Scopus

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