Konidiogenese u patogenních hub: cytoskelet jako terč antifungálních látek

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F04%3A00011438" target="_blank" >RIV/00216224:14110/04:00011438 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

CONIDIOGENESIS IN PATHOGENIC FUNGI: CYTOSKELETON AS TARGET FOR ANTIFUNGALS

Popis výsledku v původním jazyce

Recent studies have revealed the role of cytoskeleton in the fundamental morphogenetic processes in fungi, that is, those of polar and spherical growth, and in septation during budding and fission. Actin cables are engaged in cytoplasmic transport, actinrings in cytokinesis and actin patches take part in exocytosis and endocytosis on the cell surface. Microtubules are part of the mitotic spindle and also occur in the cytoplasm, taking part in nuclear movement. Conidia - asexual spores of fungi - are relatively heterogeneous in their morphogenesis. Their cytoskeleton in the course of the conidiogenesis in fungi has not been practically studied yet. Objective of our work was to identify the cytoskeletal structures and the dynamics of cytoskeleton rearrangement in the course of conidiogenesis as targets for detection of antifungals. As electron microscopic study without immunodetection is problematic, our present work was based on immunofluorescence detection of cytoskeleton. Electron mi

Název v anglickém jazyce

CONIDIOGENESIS IN PATHOGENIC FUNGI: CYTOSKELETON AS TARGET FOR ANTIFUNGALS

Popis výsledku anglicky

Recent studies have revealed the role of cytoskeleton in the fundamental morphogenetic processes in fungi, that is, those of polar and spherical growth, and in septation during budding and fission. Actin cables are engaged in cytoplasmic transport, actinrings in cytokinesis and actin patches take part in exocytosis and endocytosis on the cell surface. Microtubules are part of the mitotic spindle and also occur in the cytoplasm, taking part in nuclear movement. Conidia - asexual spores of fungi - are relatively heterogeneous in their morphogenesis. Their cytoskeleton in the course of the conidiogenesis in fungi has not been practically studied yet. Objective of our work was to identify the cytoskeletal structures and the dynamics of cytoskeleton rearrangement in the course of conidiogenesis as targets for detection of antifungals. As electron microscopic study without immunodetection is problematic, our present work was based on immunofluorescence detection of cytoskeleton. Electron mi

Druh

D - Stať ve sborníku

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

<a href="/cs/project/GA310%2F00%2F0391" target="_blank" >GA310/00/0391: Cytoskelet u lidských patogenních kvasinkových mikroorganismů.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2004

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

8th Asia-Pacific Conference on Electron Microscopy (8APEM)

ISBN

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ISSN

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e-ISSN

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Počet stran výsledku

1

Strana od-do

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Název nakladatele

Medical University Kanazawa, Japan

Místo vydání

Kanazawa, Japan

Místo konání akce

Kanazawa, Japonsko

Datum konání akce

7. 6. 2004

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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