YEAST PATHOGENS: THE CYTOSKELETON AND THE CELL WALL AS TARGETS FOR ANTIFUNGALS-INVITED LECTURE

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F10%3A00048676" target="_blank" >RIV/00216224:14110/10:00048676 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

YEAST PATHOGENS: THE CYTOSKELETON AND THE CELL WALL AS TARGETS FOR ANTIFUNGALS-INVITED LECTURE

Popis výsledku v původním jazyce

We identified the cytoskeleton in Cryptococcus neoformans, Aureobasidium pullulans, Fellomyces fuzhouensis, Cryptococcus laurentii and Malassezia pachydermatis. The cytoskeleton is involved in budding, bud-fission, hyphal growth and conidiogenesis of human yeast and fungal pathogens. We investigated the cytoskeleton as a potential target for inhibition of morphogenesis using microtubule and actin inhibitors. All microtubule inhibitors were effective, but clinical ones only transiently and resistant cells originated. Cytochalasins were not effective. Latrunculin A inhibited budding, fission, hyphal growth, conidiogenesis. The most efficient inhibition was reached by combining the microtubule and actin inhibitors (Kopecká M.,Gabriel M., Chemotherapy 2009;55:278-286). Our study provided new results of the basic research on the cytoskeleton as a new potent target for inhibition of yeast pathogens that may show the way to a new antifungal strategy.

Název v anglickém jazyce

YEAST PATHOGENS: THE CYTOSKELETON AND THE CELL WALL AS TARGETS FOR ANTIFUNGALS-INVITED LECTURE

Popis výsledku anglicky

We identified the cytoskeleton in Cryptococcus neoformans, Aureobasidium pullulans, Fellomyces fuzhouensis, Cryptococcus laurentii and Malassezia pachydermatis. The cytoskeleton is involved in budding, bud-fission, hyphal growth and conidiogenesis of human yeast and fungal pathogens. We investigated the cytoskeleton as a potential target for inhibition of morphogenesis using microtubule and actin inhibitors. All microtubule inhibitors were effective, but clinical ones only transiently and resistant cells originated. Cytochalasins were not effective. Latrunculin A inhibited budding, fission, hyphal growth, conidiogenesis. The most efficient inhibition was reached by combining the microtubule and actin inhibitors (Kopecká M.,Gabriel M., Chemotherapy 2009;55:278-286). Our study provided new results of the basic research on the cytoskeleton as a new potent target for inhibition of yeast pathogens that may show the way to a new antifungal strategy.

Druh

O - Ostatní výsledky

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

<a href="/cs/project/GA310%2F06%2F0605" target="_blank" >GA310/06/0605: Lidské patogenní houby : cytoskelet jako potenciální terč inhibice morfogeneze.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů