Laboratory for Cell Biology of Human Pathogenic Yeasts

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F10%3A00048675" target="_blank" >RIV/00216224:14110/10:00048675 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Laboratory for Cell Biology of Human Pathogenic Yeasts

Popis výsledku v původním jazyce

Our recent research identified cytoskeleton in Cryptococcus neoformans, Aureobasidium pullulans, Fellomyces fuzhouensis, Cryptococcus laurentii and Malassezia pachydermatis.The cytoskeleton is involved in budding, bud-fission, hyphal growth and conidiogenesis of human yeast and fungal pathogens. The cytoskeleton was investigated as a potential target of inhibition using microtubule and actin inhibitors. All microtubule inhibitors were effective, while clinical ones had only transient effect and resistant cells originated. Cytochalasins were not effective. Latrunculin A inhibited budding, fission, hyphal growth and conidiogenesis. The most efficient inhibition was reached by combining the microtubule and actin inhibitors(Kopecká M.,Gabriel M., Chemotherapy 2009;55:278-286). Our study brought new findings of the basic research on the cytoskeleton as a new target for inhibition of yeast human pathogens, which may show the way to a new antifungal strategy.

Název v anglickém jazyce

Laboratory for Cell Biology of Human Pathogenic Yeasts

Popis výsledku anglicky

Our recent research identified cytoskeleton in Cryptococcus neoformans, Aureobasidium pullulans, Fellomyces fuzhouensis, Cryptococcus laurentii and Malassezia pachydermatis.The cytoskeleton is involved in budding, bud-fission, hyphal growth and conidiogenesis of human yeast and fungal pathogens. The cytoskeleton was investigated as a potential target of inhibition using microtubule and actin inhibitors. All microtubule inhibitors were effective, while clinical ones had only transient effect and resistant cells originated. Cytochalasins were not effective. Latrunculin A inhibited budding, fission, hyphal growth and conidiogenesis. The most efficient inhibition was reached by combining the microtubule and actin inhibitors(Kopecká M.,Gabriel M., Chemotherapy 2009;55:278-286). Our study brought new findings of the basic research on the cytoskeleton as a new target for inhibition of yeast human pathogens, which may show the way to a new antifungal strategy.

Druh

C - Kapitola v odborné knize

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

<a href="/cs/project/GA310%2F06%2F0605" target="_blank" >GA310/06/0605: Lidské patogenní houby : cytoskelet jako potenciální terč inhibice morfogeneze.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Fifty Years of Czechoslovak Yeast Research, Period 2000-2009.

ISBN

978-80-89257-20-1

Počet stran výsledku

3

Strana od-do

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Počet stran knihy

110

Název nakladatele

Commission on Yeasts, Czechoslovak Microbiological Society

Místo vydání

Bratislava, Slovenská republika

Kód UT WoS kapitoly

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