Polymorfizmus v exonu genu pro CD14 receptor u mladých atopických pacientů v české populaci

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F05%3A00012716" target="_blank" >RIV/00216224:14110/05:00012716 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

A polymorphism in exon of the CD14 gene and atopic phenotypes in Czech young patients with IgE-mediated allergy

Popis výsledku v původním jazyce

Atopy is a generally considered to be caused by interaction of genetic and environmental factors. The gene encoding CD14 is a positional candidate gene for atopy, as it is localized on chromosome 5q31.1, a region that has been linked to asthma and atopicresponses. We investigated relationship among atopic phenotypes and the 1341G/T polymorphism in exon of the CD14 gene in the Czech population. Polymerase chain reaction with RFLP analyses were used to determine the CD14 genotypes in subjects with IgE-mediated allergic diseases (n = 290) and random controls (n = 189). IgE-mediated allergy was recognised by specific IgE or a positive skin prick test to any one or more allergens. The CD14 allele or genotype distributions were similar in patients and control group. However, when atopic patients were subdivided in subjects with positive and those with negative skin prick tests, this polymorphism was significantly associated with a positive reactivity to the mites. T allele of the 1341G/T po

Název v anglickém jazyce

A polymorphism in exon of the CD14 gene and atopic phenotypes in Czech young patients with IgE-mediated allergy

Popis výsledku anglicky

Atopy is a generally considered to be caused by interaction of genetic and environmental factors. The gene encoding CD14 is a positional candidate gene for atopy, as it is localized on chromosome 5q31.1, a region that has been linked to asthma and atopicresponses. We investigated relationship among atopic phenotypes and the 1341G/T polymorphism in exon of the CD14 gene in the Czech population. Polymerase chain reaction with RFLP analyses were used to determine the CD14 genotypes in subjects with IgE-mediated allergic diseases (n = 290) and random controls (n = 189). IgE-mediated allergy was recognised by specific IgE or a positive skin prick test to any one or more allergens. The CD14 allele or genotype distributions were similar in patients and control group. However, when atopic patients were subdivided in subjects with positive and those with negative skin prick tests, this polymorphism was significantly associated with a positive reactivity to the mites. T allele of the 1341G/T po

Druh

D - Stať ve sborníku

CEP obor

EC - Imunologie

OECD FORD obor

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Projekt

<a href="/cs/project/GP310%2F03%2FD193" target="_blank" >GP310/03/D193: Úloha polymorfizmů v genech pro receptory CD14 a TLR4 u atopických nemocí v české populaci</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2005

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

International Journal on Immunorehabilitation

ISBN

1562-3629

ISSN

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e-ISSN

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Počet stran výsledku

1

Strana od-do

74-74

Název nakladatele

III European Asthma Congress

Místo vydání

Moscow, Russia

Místo konání akce

Athens, Greece

Datum konání akce

1. 1. 2005

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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