Biologické aktivity benzo[c]phenanthridinových alkaloidů

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F05%3A00013264" target="_blank" >RIV/00216224:14110/05:00013264 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Biological effects of benzo[c]phenanthridine alkaloids.

Popis výsledku v původním jazyce

Quaternary benzo[c]phenanthridine alkaloids (QBA) are group of natural products, which are discussed as potencial cytostatics for cancer treatment. QBA are relatively small group of isoquinoline alkaloids that have phenylalanin as their precursor. They are distributed in a number of plant species of Papaveraceae, Fumariaceae and Rutaceae families. Sanguinarin and chelerythrin are the two best known QBA and their biological activities have been widely studied (1,2,3). In addition to them about 10 other QBA differing only by substitution on the aromatic rings have been isolated as a minor components. The informations about biological effects of this minor QBA are rare. In this study the differential cytotoxicity of sanguinarine (SA), chelerythrine (CHE)and their minority derivates sanguirubine (SR), chelirubine (CHR) and macarpine (MA) was assessed in vitro by MTT assay. One normal (skin fibroblasts) and 3 tumour cell lines (HeLa; A 431; HL-60) were used as a model object. After 72 hour

Název v anglickém jazyce

Biological effects of benzo[c]phenanthridine alkaloids.

Popis výsledku anglicky

Quaternary benzo[c]phenanthridine alkaloids (QBA) are group of natural products, which are discussed as potencial cytostatics for cancer treatment. QBA are relatively small group of isoquinoline alkaloids that have phenylalanin as their precursor. They are distributed in a number of plant species of Papaveraceae, Fumariaceae and Rutaceae families. Sanguinarin and chelerythrin are the two best known QBA and their biological activities have been widely studied (1,2,3). In addition to them about 10 other QBA differing only by substitution on the aromatic rings have been isolated as a minor components. The informations about biological effects of this minor QBA are rare. In this study the differential cytotoxicity of sanguinarine (SA), chelerythrine (CHE)and their minority derivates sanguirubine (SR), chelirubine (CHR) and macarpine (MA) was assessed in vitro by MTT assay. One normal (skin fibroblasts) and 3 tumour cell lines (HeLa; A 431; HL-60) were used as a model object. After 72 hour

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2005

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Applied Biomedicine

ISSN

1214-021X

e-ISSN

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Svazek periodika

3

Číslo periodika v rámci svazku

Suppl 1

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

2

Strana od-do

"S42"-"S43"

Kód UT WoS článku

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EID výsledku v databázi Scopus

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