LIQUID CHROMATOGRAPHY MASS SPECTROMETRY OF SELECTED BENZOPHENANTHRIDINE ALKALOIDS INCUBATED WITH RAT LIVER MICROSOMES

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F13%3A00070341" target="_blank" >RIV/00216224:14110/13:00070341 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

LIQUID CHROMATOGRAPHY MASS SPECTROMETRY OF SELECTED BENZOPHENANTHRIDINE ALKALOIDS INCUBATED WITH RAT LIVER MICROSOMES

Popis výsledku v původním jazyce

Quaternary benzo[c]phenantridine alkaloids (QBAs) belong to a subgroup of isoquinoline alkaloids. They include major sanguinarine (SA) and chelerythrine (CHE) as well as minor QBAs chelirubine (CR), sanguilutine (SL), sanguirubine (SR), chelilutine (CL),and macarpine (MA). The effects of QBAs on biological systems have been studied extensively, especially for commercially available SA and CHE. Limited availability of the minor pentasubstituted QBAs and hexasubstituted MA reduces data concerning their biological effects. Although the QBA molecular structures are very similar, the mechanism of their action on the molecular level may be different. As pharmacological studies imply that even a small change in the structure may trigger a significant difference in pharmacological activity, it cannot be simply accepted that metabolic routes of all QBAs will be analogous.

Název v anglickém jazyce

LIQUID CHROMATOGRAPHY MASS SPECTROMETRY OF SELECTED BENZOPHENANTHRIDINE ALKALOIDS INCUBATED WITH RAT LIVER MICROSOMES

Popis výsledku anglicky

Quaternary benzo[c]phenantridine alkaloids (QBAs) belong to a subgroup of isoquinoline alkaloids. They include major sanguinarine (SA) and chelerythrine (CHE) as well as minor QBAs chelirubine (CR), sanguilutine (SL), sanguirubine (SR), chelilutine (CL),and macarpine (MA). The effects of QBAs on biological systems have been studied extensively, especially for commercially available SA and CHE. Limited availability of the minor pentasubstituted QBAs and hexasubstituted MA reduces data concerning their biological effects. Although the QBA molecular structures are very similar, the mechanism of their action on the molecular level may be different. As pharmacological studies imply that even a small change in the structure may trigger a significant difference in pharmacological activity, it cannot be simply accepted that metabolic routes of all QBAs will be analogous.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

<a href="/cs/project/LH12176" target="_blank" >LH12176: Benzofenanthridinové alkaloidy - studium účinků na celulární a molekulární úrovni</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chemické listy

ISSN

0009-2770

e-ISSN

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Svazek periodika

107

Číslo periodika v rámci svazku

Special Issue, Supplement 3

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

2

Strana od-do

"S405"-"S406"

Kód UT WoS článku

000328730800049

EID výsledku v databázi Scopus

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