Hustota intraepidermálních nervových vláken u pacientů s neuropatií tenkých vláken s a bez současného postižení vláken silných

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F05%3A00014761" target="_blank" >RIV/00216224:14110/05:00014761 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Intra-epidermal nerve fibre density in patients with small fibre polyneuropathy with and without simultaneous large fibre involvement

Popis výsledku v původním jazyce

Background and aim: The diagnosis of small fibre neuropathy (SFN) is currently based on the clinical picture, quantitative sensory testing (QST), and autonomic function assessment. A decreased density of intraepidermal innervation seem to be morphological correlates of small-fibre dysfunction. The aim of this study was to compare intraepidermal nerve fibre (IENF) density in skin punch biopsy samples from a group of SFN patients and from healthy volunteers, then to assess the influence of simultaneous large nerve-fibre involvement on IENF counts. Methods: PGP 9.5-immunoreactive intraepidermal nerve fibre (IENF) density was measured in 67 patients with painful sensory neuropathy and in 25 healthy controls. All the patients suffered from burning feet, andshowed abnormal thermal thresholds on QST. Of the patients, 29 also revealed abnormities in nerve conduction studies and EMG examination, signs of large fibre involvement. Results: The mean IENF count per mm of epidermis was 5.8ą4.3 in t

Název v anglickém jazyce

Intra-epidermal nerve fibre density in patients with small fibre polyneuropathy with and without simultaneous large fibre involvement

Popis výsledku anglicky

Background and aim: The diagnosis of small fibre neuropathy (SFN) is currently based on the clinical picture, quantitative sensory testing (QST), and autonomic function assessment. A decreased density of intraepidermal innervation seem to be morphological correlates of small-fibre dysfunction. The aim of this study was to compare intraepidermal nerve fibre (IENF) density in skin punch biopsy samples from a group of SFN patients and from healthy volunteers, then to assess the influence of simultaneous large nerve-fibre involvement on IENF counts. Methods: PGP 9.5-immunoreactive intraepidermal nerve fibre (IENF) density was measured in 67 patients with painful sensory neuropathy and in 25 healthy controls. All the patients suffered from burning feet, andshowed abnormal thermal thresholds on QST. Of the patients, 29 also revealed abnormities in nerve conduction studies and EMG examination, signs of large fibre involvement. Results: The mean IENF count per mm of epidermis was 5.8ą4.3 in t

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

—

Projekt

—

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2005

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Journal of Neurology

ISSN

1351-5101

e-ISSN

—

Svazek periodika

2005

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

1

Strana od-do

219

Kód UT WoS článku

—

EID výsledku v databázi Scopus

—