Hustota intraepidermálních nervových vláken u pacientů s neuropatií tenkých vláken s a bez současného postižení vláken silných

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F05%3A00014762" target="_blank" >RIV/00216224:14110/05:00014762 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Intraepidermal nerve fibre density in patients with small fibre polyneuropathy with and without simultaneous large fibre affection

Popis výsledku v původním jazyce

Background and Aims: The diagnosis of small fibre neuropathy (SFN) is currently based on the clinical picture, quantitative sensory testing (QST), and autonomic function assessment. Decreased density of and structural abnormities in intraepidermal innervation seem to be morphological correlates of small-fibre dysfunction, and recent studies emphasize the importance of skin biopsy examination in painful sensory neuropathies. The aim of this study was to compare intraepidermal nerve fibre (IENF) density in skin punch biopsy samples in a group of SFN patients with healthy volunteers, and to assess the influence of simultaneous large nerve-fibre involvement on IENF counts. Methods: PGP 9.5-immunoreactive intraepidermal nerve fibre (IENF) density was measured in 76 patients with painful sensory neuropathy and in 25 healthy controls. All patients suffered from subacete or chronic distal sensory symptoms with burning feet and had abnormal thermal thresholds in QST. 42 of the patients also had

Název v anglickém jazyce

Intraepidermal nerve fibre density in patients with small fibre polyneuropathy with and without simultaneous large fibre affection

Popis výsledku anglicky

Background and Aims: The diagnosis of small fibre neuropathy (SFN) is currently based on the clinical picture, quantitative sensory testing (QST), and autonomic function assessment. Decreased density of and structural abnormities in intraepidermal innervation seem to be morphological correlates of small-fibre dysfunction, and recent studies emphasize the importance of skin biopsy examination in painful sensory neuropathies. The aim of this study was to compare intraepidermal nerve fibre (IENF) density in skin punch biopsy samples in a group of SFN patients with healthy volunteers, and to assess the influence of simultaneous large nerve-fibre involvement on IENF counts. Methods: PGP 9.5-immunoreactive intraepidermal nerve fibre (IENF) density was measured in 76 patients with painful sensory neuropathy and in 25 healthy controls. All patients suffered from subacete or chronic distal sensory symptoms with burning feet and had abnormal thermal thresholds in QST. 42 of the patients also had

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2005

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of the Peripheral Nervous System

ISSN

1085-9489

e-ISSN

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Svazek periodika

2005

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

1

Strana od-do

63

Kód UT WoS článku

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EID výsledku v databázi Scopus

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