Hodnocení intraepidermální hustoty tenkých nervových vláken z kožní biopsie

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F05%3A00014804" target="_blank" >RIV/00216224:14110/05:00014804 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The evaluation of intraepidermal nerve fiber density from skin punch biopsy samples

Popis výsledku v původním jazyce

Painful sensory neuropathies with exclusive or preferential affection of small sensory nerve fibers (SFN) of the A-delta and C types are commonly encountered in clinical practice. The diagnostic evaluation of SFN frequently represents a problem, since, unless there is associated large-fiber involvement, patients display only few abnormities on clinical neurological examination and have normal nerve conduction studies. The method most frequently used for the diagnosis of small nerve fibers affection in clinical practice is thermal threshold testing. With respect to its psychophysical character, new method of small nerve fiber evaluation has recently been found. This method is based on the visualisation of PGP 9,5-immunoreactive skin neural structures and on quantification of intraepidermal nerve fiber density (IENFD). We use the lower limit of normal intraepidermal innervation on the level of 6,69 fibers per millimeter of the epidermal length. The method is easy to perform, minimally in

Název v anglickém jazyce

The evaluation of intraepidermal nerve fiber density from skin punch biopsy samples

Popis výsledku anglicky

Painful sensory neuropathies with exclusive or preferential affection of small sensory nerve fibers (SFN) of the A-delta and C types are commonly encountered in clinical practice. The diagnostic evaluation of SFN frequently represents a problem, since, unless there is associated large-fiber involvement, patients display only few abnormities on clinical neurological examination and have normal nerve conduction studies. The method most frequently used for the diagnosis of small nerve fibers affection in clinical practice is thermal threshold testing. With respect to its psychophysical character, new method of small nerve fiber evaluation has recently been found. This method is based on the visualisation of PGP 9,5-immunoreactive skin neural structures and on quantification of intraepidermal nerve fiber density (IENFD). We use the lower limit of normal intraepidermal innervation on the level of 6,69 fibers per millimeter of the epidermal length. The method is easy to perform, minimally in

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2005

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Česká a slovenská neurologie a neurochirurgie

ISSN

1210-7859

e-ISSN

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Svazek periodika

68

Číslo periodika v rámci svazku

101

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

1

Strana od-do

277

Kód UT WoS článku

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EID výsledku v databázi Scopus

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