Effect of ajmaline on course of action potential and ionic membrane currents in rat ventricular myocytes

Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F05%3A00021928" target="_blank" >RIV/00216224:14110/05:00021928 - isvavai.cz</a>
Výsledek na webu
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DOI - Digital Object Identifier
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Jazyk výsledku
angličtina
Název v původním jazyce
Effect of ajmaline on course of action potential and ionic membrane currents in rat ventricular myocytes
Popis výsledku v původním jazyce
Ajmaline decreased the upstroke velocity of action potential and its amplitude, very likely by inhibition of sodium current INa. The observed prolongation of action potential was probably related to the inhibition of transient outward potassium current Ito, the main repolarizing current in rat. This effect predominates over the opposite effect of the inhibition of calcium current ICaL, partly because of lower IC50.
Název v anglickém jazyce
Effect of ajmaline on course of action potential and ionic membrane currents in rat ventricular myocytes
Popis výsledku anglicky
Ajmaline decreased the upstroke velocity of action potential and its amplitude, very likely by inhibition of sodium current INa. The observed prolongation of action potential was probably related to the inhibition of transient outward potassium current Ito, the main repolarizing current in rat. This effect predominates over the opposite effect of the inhibition of calcium current ICaL, partly because of lower IC50.

Rok uplatnění
2005
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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