Funkční role srdečních T-tubulů v modelu komorové buňky krysy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F06%3A00015542" target="_blank" >RIV/00216224:14110/06:00015542 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61388998:_____/06:00041960

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The functional role of cardiac T-tubules in a model of rat ventricular myocytes

Popis výsledku v původním jazyce

The morphology of the cardiac transverse axial tubular system (TATS) has been known for decades, but its function has received little attention. To explore the possible role of this system in the physiological modulation of electrical and contractile activity, we have developed a mathematical model of rat ventricular cardiomyocytes in which the TATS is described as a single compartment. In the model, the action potentials initiated in current clamp mode were accompanied by transient K+ accumulation andtransient Ca2+ depletion in the TATS lumen. The amplitude of these changes relative to external ion concentrations was studied at steady state stimulation frequencies of 1 to 5 Hz. Ca2+ depletion increased from 7 % to 13.1 % with stimulation frequency, while K+ accumulation decreased from 4.1 % to 2.7 %. These ionic changes (particularly Ca2+ depletion) implicated significant decrease of intracellular Ca2+ load at frequencies natural for rat heart.

Název v anglickém jazyce

The functional role of cardiac T-tubules in a model of rat ventricular myocytes

Popis výsledku anglicky

The morphology of the cardiac transverse axial tubular system (TATS) has been known for decades, but its function has received little attention. To explore the possible role of this system in the physiological modulation of electrical and contractile activity, we have developed a mathematical model of rat ventricular cardiomyocytes in which the TATS is described as a single compartment. In the model, the action potentials initiated in current clamp mode were accompanied by transient K+ accumulation andtransient Ca2+ depletion in the TATS lumen. The amplitude of these changes relative to external ion concentrations was studied at steady state stimulation frequencies of 1 to 5 Hz. Ca2+ depletion increased from 7 % to 13.1 % with stimulation frequency, while K+ accumulation decreased from 4.1 % to 2.7 %. These ionic changes (particularly Ca2+ depletion) implicated significant decrease of intracellular Ca2+ load at frequencies natural for rat heart.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

BO - Biofyzika

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2006

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Philosophical Transactions of the Royal Society

ISSN

1364-503X

e-ISSN

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Svazek periodika

364

Číslo periodika v rámci svazku

1842

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

20

Strana od-do

1187-1206

Kód UT WoS článku

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EID výsledku v databázi Scopus

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