SNPs in adipokines - adiponectin and leptin - as risk factors for diabetic complications: evidence for a "double-hit" mechanism?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F07%3A00019377" target="_blank" >RIV/00216224:14110/07:00019377 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

SNPs in adipokines - adiponectin and leptin - as risk factors for diabetic complications: evidence for a "double-hit" mechanism?

Popis výsledku v původním jazyce

Diabetic angiopathy is now recognized as an inflammatory process of the vessel wall. Type 2 diabetes (T2DM) is far the most common type frequently accompanied by obesity in affected subjects. Co-occurrence of both diseases is not just an epidemiologicalassociation but a likely consequence of common ethiopathogenesis. Adipokines too play multiple roles in inflammation ultimately activating, similarly to hyperglycemia itself, transcription factor NFkB with subsequent inflammatory changes in vascular tissue. Leptin (LEP) and adiponectin (APM1) are, apart of their role in energy homeostasis, examples of vascular pro- and anti-inflammatory mediators, respectively. Genetic variability in the APM1 and LEP genes could not only modulate the risk of obesity and/or T2DM but also influence susceptibility to the development of diabetic complications.

Název v anglickém jazyce

SNPs in adipokines - adiponectin and leptin - as risk factors for diabetic complications: evidence for a "double-hit" mechanism?

Popis výsledku anglicky

Diabetic angiopathy is now recognized as an inflammatory process of the vessel wall. Type 2 diabetes (T2DM) is far the most common type frequently accompanied by obesity in affected subjects. Co-occurrence of both diseases is not just an epidemiologicalassociation but a likely consequence of common ethiopathogenesis. Adipokines too play multiple roles in inflammation ultimately activating, similarly to hyperglycemia itself, transcription factor NFkB with subsequent inflammatory changes in vascular tissue. Leptin (LEP) and adiponectin (APM1) are, apart of their role in energy homeostasis, examples of vascular pro- and anti-inflammatory mediators, respectively. Genetic variability in the APM1 and LEP genes could not only modulate the risk of obesity and/or T2DM but also influence susceptibility to the development of diabetic complications.

Druh

O - Ostatní výsledky

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

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Projekt

<a href="/cs/project/KJB501620601" target="_blank" >KJB501620601: Funkční analýza rizikového haplotypu RAGE genu a jeho role v patogenezi hyperglykemií indukovaných změn</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2007

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů