Adipokine gene variability and plasma levels in patients with chronic periodontitis - a case-control study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F19%3A00107509" target="_blank" >RIV/00216224:14110/19:00107509 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1590/1807-3107bor-2019.vol33.0034" target="_blank" >http://dx.doi.org/10.1590/1807-3107bor-2019.vol33.0034</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1590/1807-3107bor-2019.vol33.0034" target="_blank" >10.1590/1807-3107bor-2019.vol33.0034</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Adipokine gene variability and plasma levels in patients with chronic periodontitis - a case-control study

Popis výsledku v původním jazyce

Specific variants in genes that encode adipokines and their mRNA and protein expression were previously studied in type 2 diabetes mellitus (T2DM) and obesity, and similar studies have been performed for chronic periodontitis (CP). The aim of this case-control study was to investigate the possible impacts of adiponectin (ADIPOQ), leptin (LEP) and its receptor (LEPR), and resistin (RETN) on the etiopathogenesis of CP. Examinations were performed on 118 non-periodontitis healthy subjects (healthy controls, HC), 205 healthy individuals with CP (H + CP) and 86 type 2 diabetes patients with CP (T2DM + CP). Variants within the ADIPOQ (rs2241766, rs1501299), LEP (rs13228377, rs2167270), LEP receptor (rs1805096), and RETN (rs1862513) genes were determined by qPCR. In addition, the plasma levels of ADIPOQ, LEP, and RETN were analysed by ELISA for 80 individuals. The genotype frequencies of the SNP ADIPOQ + 45G/T (rs2241766) differed between the HC and H + CP groups (p=0.03, p(corr)&gt;0.05), and carriers of the TT genotype had a lower risk of developing CP compared to carriers of the GG or TG genotypes (p&lt;0.01, p(corr)&gt;0.05). However, there were no significant differences in the plasma levels of ADIPOQ, LEP or RETN between the study groups (p &gt; 0.05). Plasma levels of the adipokines were also independent of the gene profiles (p &gt; 0.05). Adipokine plasma levels did not change in patients with H + CP/T2DM + CP compared to HC, but we did identify a specific polymorphism in the ADIPOQ gene that was associated with CP. Although the ADIPOQ + 45G/T (rs2241766) gene variant may be a candidate biomarker for CP, further research is required in larger populations with different ethnic backgrounds before any final conclusions can be drawn about the role of this gene in CP.

Název v anglickém jazyce

Adipokine gene variability and plasma levels in patients with chronic periodontitis - a case-control study

Popis výsledku anglicky

Specific variants in genes that encode adipokines and their mRNA and protein expression were previously studied in type 2 diabetes mellitus (T2DM) and obesity, and similar studies have been performed for chronic periodontitis (CP). The aim of this case-control study was to investigate the possible impacts of adiponectin (ADIPOQ), leptin (LEP) and its receptor (LEPR), and resistin (RETN) on the etiopathogenesis of CP. Examinations were performed on 118 non-periodontitis healthy subjects (healthy controls, HC), 205 healthy individuals with CP (H + CP) and 86 type 2 diabetes patients with CP (T2DM + CP). Variants within the ADIPOQ (rs2241766, rs1501299), LEP (rs13228377, rs2167270), LEP receptor (rs1805096), and RETN (rs1862513) genes were determined by qPCR. In addition, the plasma levels of ADIPOQ, LEP, and RETN were analysed by ELISA for 80 individuals. The genotype frequencies of the SNP ADIPOQ + 45G/T (rs2241766) differed between the HC and H + CP groups (p=0.03, p(corr)&gt;0.05), and carriers of the TT genotype had a lower risk of developing CP compared to carriers of the GG or TG genotypes (p&lt;0.01, p(corr)&gt;0.05). However, there were no significant differences in the plasma levels of ADIPOQ, LEP or RETN between the study groups (p &gt; 0.05). Plasma levels of the adipokines were also independent of the gene profiles (p &gt; 0.05). Adipokine plasma levels did not change in patients with H + CP/T2DM + CP compared to HC, but we did identify a specific polymorphism in the ADIPOQ gene that was associated with CP. Although the ADIPOQ + 45G/T (rs2241766) gene variant may be a candidate biomarker for CP, further research is required in larger populations with different ethnic backgrounds before any final conclusions can be drawn about the role of this gene in CP.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30208 - Dentistry, oral surgery and medicine

Projekt

<a href="/cs/project/GB14-37368G" target="_blank" >GB14-37368G: Centrum orofaciálního vývoje a regenerace</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

BRAZILIAN ORAL RESEARCH

ISSN

1807-3107

e-ISSN

—

Svazek periodika

33

Číslo periodika v rámci svazku

e034

Stát vydavatele periodika

BR - Brazilská federativní republika

Počet stran výsledku

12

Strana od-do

1-12

Kód UT WoS článku

000468342300001

EID výsledku v databázi Scopus

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