Rate constants of open channel block of cardiac transient outward current

Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F07%3A00041745" target="_blank" >RIV/00216224:14110/07:00041745 - isvavai.cz</a>
Výsledek na webu
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DOI - Digital Object Identifier
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Jazyk výsledku
angličtina
Název v původním jazyce
Rate constants of open channel block of cardiac transient outward current
Popis výsledku v původním jazyce
Numerous drugs used in clinical cardiology are blockers of membrane channels. Some of them have access to their binding sites only in open channel state. The aim of this study was to elaborate an improved approach to the assessment of association and dissociation rate constants of drug-channel interaction. The increased accuracy of the calculation of rate constants according to the newly proposed formula was verified by simulations on a quantitative model that included channel gating and drug-channel interaction.
Název v anglickém jazyce
Rate constants of open channel block of cardiac transient outward current
Popis výsledku anglicky
Numerous drugs used in clinical cardiology are blockers of membrane channels. Some of them have access to their binding sites only in open channel state. The aim of this study was to elaborate an improved approach to the assessment of association and dissociation rate constants of drug-channel interaction. The increased accuracy of the calculation of rate constants according to the newly proposed formula was verified by simulations on a quantitative model that included channel gating and drug-channel interaction.

Rok uplatnění
2007
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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