Cytokine response in severe sepsis - predicting the course of illness in adult and paediatric patients

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Cytokine response in severe sepsis - predicting the course of illness in adult and paediatric patients

Popis výsledku v původním jazyce

During the progression of sepsis from early hit to multiorgan failure proinflammatory and anti-inflammatory cytokines are released. Cytokines can be used as biomarkers to determine the specific patterns of sepsis progression and association with mortality. In our study CRP levels correlated with the probability of survival, following levels of TREM-1, PCT and IL-6. Contrary to CRP and PCT levels, which rapidly fell during the first study days, levels of cytokines and TREM-I remained elevated throughoutthe study period, but were not so high and even normal in these subjects with severe sepsis despite early enrolment. Severity of disease at presentation correlated with levels of CRP, PCT, TREM-1, IL-6, IL-12, IL-4, IL-1 beta and TNF, especially in children. Response of circulating cytokines in patients with severe sepsis is heterogeneous in adults and children population and there is a specific pattern of this response related to mortality and severity at presentation.

Název v anglickém jazyce

Cytokine response in severe sepsis - predicting the course of illness in adult and paediatric patients

Popis výsledku anglicky

During the progression of sepsis from early hit to multiorgan failure proinflammatory and anti-inflammatory cytokines are released. Cytokines can be used as biomarkers to determine the specific patterns of sepsis progression and association with mortality. In our study CRP levels correlated with the probability of survival, following levels of TREM-1, PCT and IL-6. Contrary to CRP and PCT levels, which rapidly fell during the first study days, levels of cytokines and TREM-I remained elevated throughoutthe study period, but were not so high and even normal in these subjects with severe sepsis despite early enrolment. Severity of disease at presentation correlated with levels of CRP, PCT, TREM-1, IL-6, IL-12, IL-4, IL-1 beta and TNF, especially in children. Response of circulating cytokines in patients with severe sepsis is heterogeneous in adults and children population and there is a specific pattern of this response related to mortality and severity at presentation.

Druh

D - Stať ve sborníku

CEP obor

FN - Epidemiologie, infekční nemoci a klinická imunologie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Proceedings of the 8th World Congress on Trauma, Shock, Inflammation and Sepsis, Selected Papers

ISBN

978-88-6521-024-6

ISSN

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e-ISSN

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Počet stran výsledku

5

Strana od-do

33-37

Název nakladatele

Thomson Reuters

Místo vydání

Philadelphia

Místo konání akce

Munich, Germany

Datum konání akce

9. 3. 2010

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

000281967800007