CHEK2 gene alterations in the forkhead-associated domain, 1100delC and del5395 do not modify risk of sporadic pancreatic cancer

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F10%3A00051816" target="_blank" >RIV/00216224:14110/10:00051816 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.canep.2010.06.008" target="_blank" >http://dx.doi.org/10.1016/j.canep.2010.06.008</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.canep.2010.06.008" target="_blank" >10.1016/j.canep.2010.06.008</a>

Jazyk výsledku

angličtina

Název v původním jazyce

CHEK2 gene alterations in the forkhead-associated domain, 1100delC and del5395 do not modify risk of sporadic pancreatic cancer

Popis výsledku v původním jazyce

Checkpoint kinase 2 gene (CHEK2) alterations increase risk of several cancer types. We analyzed selected CHEK2 alterations in 270 Czech pancreatic cancer patients and in 683 healthy controls. The pancreatic cancer risk was higher in individuals who inherited rare alterations in CHEK2 region involving forkhead-associated domain other than I157T (OR = 5.14; 95% Cl = 0.94-28.23) but the observed association was non-significant (p = 0.057). The most frequent I157T mutation did not alter the pancreatic cancer risk and neither the followed deletion of 5395 bp nor c.1100delC were found in any of pancreatic cases. We conclude that the I157T, other alterations in its proximity, del5395 and c.1100delC in CHEK2 do not predispose to pancreatic cancer risk in the Czech population.

Název v anglickém jazyce

CHEK2 gene alterations in the forkhead-associated domain, 1100delC and del5395 do not modify risk of sporadic pancreatic cancer

Popis výsledku anglicky

Checkpoint kinase 2 gene (CHEK2) alterations increase risk of several cancer types. We analyzed selected CHEK2 alterations in 270 Czech pancreatic cancer patients and in 683 healthy controls. The pancreatic cancer risk was higher in individuals who inherited rare alterations in CHEK2 region involving forkhead-associated domain other than I157T (OR = 5.14; 95% Cl = 0.94-28.23) but the observed association was non-significant (p = 0.057). The most frequent I157T mutation did not alter the pancreatic cancer risk and neither the followed deletion of 5395 bp nor c.1100delC were found in any of pancreatic cases. We conclude that the I157T, other alterations in its proximity, del5395 and c.1100delC in CHEK2 do not predispose to pancreatic cancer risk in the Czech population.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Cancer epidemiology

ISSN

1877-7821

e-ISSN

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Svazek periodika

34

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

3

Strana od-do

656-658

Kód UT WoS článku

000283974700024

EID výsledku v databázi Scopus

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