Expression and characterization of c-Myb in prenatal odontogenesis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F11%3A00053073" target="_blank" >RIV/00216224:14110/11:00053073 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985904:_____/11:00368272

Výsledek na webu

<a href="http://dx.doi.org/10.1111/j.1440-169X.2011.01287.x" target="_blank" >http://dx.doi.org/10.1111/j.1440-169X.2011.01287.x</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/j.1440-169X.2011.01287.x" target="_blank" >10.1111/j.1440-169X.2011.01287.x</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Expression and characterization of c-Myb in prenatal odontogenesis

Popis výsledku v původním jazyce

The transcription factor c-Myb is involved in the control of cell proliferation, survival and differentiation. As these processes accompany the morphogenesis of developing teeth, this work investigates the possible role of c-Myb during odontogenesis. Analysis of the expression of c-Myb in the monophyodont mouse was followed by similar analysis in a diphyodont species, the pig, which has a dentition more closely resembling that of the human. The distribution of c-Myb was correlated with the pattern of proliferation and apoptosis and the tooth phenotype of c-Myb mutant mice was also assessed. In the mouse, c-Myb expression was detected throughout prenatal development of the first molar tooth. Negative temporospatial correlation was found between c-Myb expression and apoptosis, while c-Myb expression positively correlated with proliferation. c-Myb-positive cells, however, were more abundant than the proliferating cell nuclear antigen positive cells, suggesting other roles of c-Myb in odon

Název v anglickém jazyce

Expression and characterization of c-Myb in prenatal odontogenesis

Popis výsledku anglicky

The transcription factor c-Myb is involved in the control of cell proliferation, survival and differentiation. As these processes accompany the morphogenesis of developing teeth, this work investigates the possible role of c-Myb during odontogenesis. Analysis of the expression of c-Myb in the monophyodont mouse was followed by similar analysis in a diphyodont species, the pig, which has a dentition more closely resembling that of the human. The distribution of c-Myb was correlated with the pattern of proliferation and apoptosis and the tooth phenotype of c-Myb mutant mice was also assessed. In the mouse, c-Myb expression was detected throughout prenatal development of the first molar tooth. Negative temporospatial correlation was found between c-Myb expression and apoptosis, while c-Myb expression positively correlated with proliferation. c-Myb-positive cells, however, were more abundant than the proliferating cell nuclear antigen positive cells, suggesting other roles of c-Myb in odon

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Development, Growth and Differentiation

ISSN

0012-1592

e-ISSN

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Svazek periodika

53

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

11

Strana od-do

793-803

Kód UT WoS článku

000293902200004

EID výsledku v databázi Scopus

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