MicroRNAs and glioblastoma: roles in core signalling pathways and potential clinical implications

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F11%3A00055225" target="_blank" >RIV/00216224:14110/11:00055225 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/65269705:_____/11:#0001592 RIV/00209805:_____/11:#0000191

Výsledek na webu

<a href="http://dx.doi.org/10.1111/j.1582-4934.2011.01317.x" target="_blank" >http://dx.doi.org/10.1111/j.1582-4934.2011.01317.x</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/j.1582-4934.2011.01317.x" target="_blank" >10.1111/j.1582-4934.2011.01317.x</a>

Jazyk výsledku

angličtina

Název v původním jazyce

MicroRNAs and glioblastoma: roles in core signalling pathways and potential clinical implications

Popis výsledku v původním jazyce

MicroRNAs (miRNAs) are endogenously expressed small non-coding RNAs that act as post-transcriptional regulators of gene expression. Dysregulation of these molecules has been indicated in the development of many cancers. Altered expression levels of several miRNAs were identified also in glioblastoma. It was repeatedly found that miRNAs are involved in important signalling pathways, which play roles in crucial cellular processes, such as proliferation, apoptosis, cell cycle regulation, invasion, angiogenesis and stem cell behaviour. Therefore, miRNAs represent promising therapeutic targets in glioblastoma. In this review, we summarize the current knowledge about miRNAs significance in glioblastoma, with special focus on their involvement in core signalling pathways, their roles in drug resistance and potential clinical implications.

Název v anglickém jazyce

MicroRNAs and glioblastoma: roles in core signalling pathways and potential clinical implications

Popis výsledku anglicky

MicroRNAs (miRNAs) are endogenously expressed small non-coding RNAs that act as post-transcriptional regulators of gene expression. Dysregulation of these molecules has been indicated in the development of many cancers. Altered expression levels of several miRNAs were identified also in glioblastoma. It was repeatedly found that miRNAs are involved in important signalling pathways, which play roles in crucial cellular processes, such as proliferation, apoptosis, cell cycle regulation, invasion, angiogenesis and stem cell behaviour. Therefore, miRNAs represent promising therapeutic targets in glioblastoma. In this review, we summarize the current knowledge about miRNAs significance in glioblastoma, with special focus on their involvement in core signalling pathways, their roles in drug resistance and potential clinical implications.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

<a href="/cs/project/NT11214" target="_blank" >NT11214: Identifikace a funkční charakterizace mikroRNA s prediktivním významem u pacientů s glioblastomem</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Cellular and Molecular Medicine

ISSN

1582-1838

e-ISSN

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Svazek periodika

15

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

1636-1644

Kód UT WoS článku

000292700800002

EID výsledku v databázi Scopus

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