Global microRNA Expression Analysis of Sox-2 positive and Negative Glioblastoma Cells

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F16%3A00088901" target="_blank" >RIV/00216224:14110/16:00088901 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/65269705:_____/16:00065889 RIV/00216224:14110/16:00088921

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Global microRNA Expression Analysis of Sox-2 positive and Negative Glioblastoma Cells

Popis výsledku v původním jazyce

Glioblastoma multiforme (GBM) is the most often occuring intracranial malignity of astrocyte origin in adults. This tumor disease is characterized by infaust prognosis, which is primarily caused by resistance to the therapy and early relapses relate to the presence of glioblastoma stem cells (GSCs). Targeting of GSCs could be a novel promising therapeutic approach leading to the overcome of therapy resistance and better prognosis of GBM patients. One of the approaches how to successfully regulate GSC is a targeted regulation of microRNAs (miRNAs). These small non-coding RNA molecules post-transcriptionally regulate an expression of more than 2/3 of all human genes that are also involved in stem cell associated signalling pathways.

Název v anglickém jazyce

Global microRNA Expression Analysis of Sox-2 positive and Negative Glioblastoma Cells

Popis výsledku anglicky

Glioblastoma multiforme (GBM) is the most often occuring intracranial malignity of astrocyte origin in adults. This tumor disease is characterized by infaust prognosis, which is primarily caused by resistance to the therapy and early relapses relate to the presence of glioblastoma stem cells (GSCs). Targeting of GSCs could be a novel promising therapeutic approach leading to the overcome of therapy resistance and better prognosis of GBM patients. One of the approaches how to successfully regulate GSC is a targeted regulation of microRNAs (miRNAs). These small non-coding RNA molecules post-transcriptionally regulate an expression of more than 2/3 of all human genes that are also involved in stem cell associated signalling pathways.

Druh

O - Ostatní výsledky

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů