Isolated Atrioventricular Block in the Fetus. A Retrospective, Multinational, Multicenter Study of 175 Patients

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F11%3A00055712" target="_blank" >RIV/00216224:14110/11:00055712 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064203:_____/11:7639

Výsledek na webu

<a href="http://dx.doi.org/10.1161/CIRCULATIONAHA.111.041970" target="_blank" >http://dx.doi.org/10.1161/CIRCULATIONAHA.111.041970</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1161/CIRCULATIONAHA.111.041970" target="_blank" >10.1161/CIRCULATIONAHA.111.041970</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Isolated Atrioventricular Block in the Fetus. A Retrospective, Multinational, Multicenter Study of 175 Patients

Popis výsledku v původním jazyce

Isolated complete atrioventricular block in the fetus is a rare but potentially lethal condition in which the effect of steroid treatment on outcome is unclear. The objective of this work was to study risk factors associated with death and the influenceof steroid treatment on outcome. Methods and Results-We studied 175 fetuses diagnosed with second-or third-degree atrioventricular block (2000-2007) retrospectively in a multinational, multicenter setting. In 80% of 162 pregnancies with documented antibody status, atrioventricular block was associated with maternal anti-Ro/SSA antibodies. Sixty-seven cases (38%) were treated with fluorinated corticosteroids for a median of 10 weeks (1-21 weeks). Ninety-one percent were alive at birth, and survival in the neonatal period was 93%, similar in steroid-treated and untreated fetuses, regardless of degree of block and/or presence of anti-Ro/SSA.

Název v anglickém jazyce

Isolated Atrioventricular Block in the Fetus. A Retrospective, Multinational, Multicenter Study of 175 Patients

Popis výsledku anglicky

Isolated complete atrioventricular block in the fetus is a rare but potentially lethal condition in which the effect of steroid treatment on outcome is unclear. The objective of this work was to study risk factors associated with death and the influenceof steroid treatment on outcome. Methods and Results-We studied 175 fetuses diagnosed with second-or third-degree atrioventricular block (2000-2007) retrospectively in a multinational, multicenter setting. In 80% of 162 pregnancies with documented antibody status, atrioventricular block was associated with maternal anti-Ro/SSA antibodies. Sixty-seven cases (38%) were treated with fluorinated corticosteroids for a median of 10 weeks (1-21 weeks). Ninety-one percent were alive at birth, and survival in the neonatal period was 93%, similar in steroid-treated and untreated fetuses, regardless of degree of block and/or presence of anti-Ro/SSA.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

CIRCULATION

ISSN

0009-7322

e-ISSN

—

Svazek periodika

124

Číslo periodika v rámci svazku

18

Stát vydavatele periodika

SE - Švédské království

Počet stran výsledku

8

Strana od-do

1919-1926

Kód UT WoS článku

000296593800014

EID výsledku v databázi Scopus

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