Apolipoprotein E Polymorphism Is Associated with Both Number of Diseased Vessels and Extent of Coronary Artery Disease in Czech Patients with CAD

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F12%3A00059806" target="_blank" >RIV/00216224:14110/12:00059806 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00159816:_____/12:#0000849

Výsledek na webu

<a href="http://dx.doi.org/10.5507/bp.2012.051" target="_blank" >http://dx.doi.org/10.5507/bp.2012.051</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5507/bp.2012.051" target="_blank" >10.5507/bp.2012.051</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Apolipoprotein E Polymorphism Is Associated with Both Number of Diseased Vessels and Extent of Coronary Artery Disease in Czech Patients with CAD

Popis výsledku v původním jazyce

Aims. The impact of ApoE polymorphism on angiographic parameters was assessed in patients referred for coronary angiography. Methods. Elective coronary angiography was performed in 671 subjects (525 men, 146 women, mean age 60+/-10 years) with symptoms of ischemic heart disease. The patients were divided into: no CAD group (smooth coronary vessels, n=83), one-vessel (n=155), two-vessel (n=170) and three-vessel disease (n=196). Patients with stenoses 0-50% were excluded. Within patients with CAD, we evaluated overall extent of CAD measured by the number of stenotic segments according to AHA (1 segment vs. 2?3 vs. more than 4), and the severity of the most serious stenosis (in percent). ApoE genotype was determined using real-time PCR. Results. The frequency of epsilon2/epsilon3 genotype (n=56) was lower in the three-vessel disease group compared to one-vessel disease (OR=0.25, P=0.0019), two-vessel disease (OR=0.31, P=0.0114) or no CAD group (OR=0.24, P=0.0057).

Název v anglickém jazyce

Apolipoprotein E Polymorphism Is Associated with Both Number of Diseased Vessels and Extent of Coronary Artery Disease in Czech Patients with CAD

Popis výsledku anglicky

Aims. The impact of ApoE polymorphism on angiographic parameters was assessed in patients referred for coronary angiography. Methods. Elective coronary angiography was performed in 671 subjects (525 men, 146 women, mean age 60+/-10 years) with symptoms of ischemic heart disease. The patients were divided into: no CAD group (smooth coronary vessels, n=83), one-vessel (n=155), two-vessel (n=170) and three-vessel disease (n=196). Patients with stenoses 0-50% were excluded. Within patients with CAD, we evaluated overall extent of CAD measured by the number of stenotic segments according to AHA (1 segment vs. 2?3 vs. more than 4), and the severity of the most serious stenosis (in percent). ApoE genotype was determined using real-time PCR. Results. The frequency of epsilon2/epsilon3 genotype (n=56) was lower in the three-vessel disease group compared to one-vessel disease (OR=0.25, P=0.0019), two-vessel disease (OR=0.31, P=0.0114) or no CAD group (OR=0.24, P=0.0057).

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomedical Papers

ISSN

1213-8118

e-ISSN

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Svazek periodika

156

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

8

Strana od-do

151-158

Kód UT WoS článku

000306401700010

EID výsledku v databázi Scopus

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