Spectrometric and Electrochemical Analysis of Sarcosine as a Potential Prostate Carcinoma Marker

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F12%3A00059961" target="_blank" >RIV/00216224:14110/12:00059961 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/62156489:43210/12:00187242 RIV/00216305:26620/12:PU98520

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Spectrometric and Electrochemical Analysis of Sarcosine as a Potential Prostate Carcinoma Marker

Popis výsledku v původním jazyce

Sarcosine, also known as N-methylglycine, is a natural ubiquitous non/protein amino acid which occurs as intermediate and side product in glycine synthesis and degradation. Recently, sarcosine has been investigated as a new putative marker in relation toprostate cancer. Sarcosine was identified as a differential metabolite that was greatly increased during prostate cancer progression to metastasis and could be detected in urine. It was also shown, that sarcosine addition to benign prostate cell cultures caused increase of their invasivity and motility. The aim of our study was to propose a low-cost, robust and simple method suitable for sarcosine determination in biological samples such as urine or blood plasma. For this purpose an ion exchange liquidchromatography as robust separation method was tested however this method suffers from insufficient limit of detection at the level of 70 microM of sarcosine.

Název v anglickém jazyce

Spectrometric and Electrochemical Analysis of Sarcosine as a Potential Prostate Carcinoma Marker

Popis výsledku anglicky

Sarcosine, also known as N-methylglycine, is a natural ubiquitous non/protein amino acid which occurs as intermediate and side product in glycine synthesis and degradation. Recently, sarcosine has been investigated as a new putative marker in relation toprostate cancer. Sarcosine was identified as a differential metabolite that was greatly increased during prostate cancer progression to metastasis and could be detected in urine. It was also shown, that sarcosine addition to benign prostate cell cultures caused increase of their invasivity and motility. The aim of our study was to propose a low-cost, robust and simple method suitable for sarcosine determination in biological samples such as urine or blood plasma. For this purpose an ion exchange liquidchromatography as robust separation method was tested however this method suffers from insufficient limit of detection at the level of 70 microM of sarcosine.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CG - Elektrochemie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Electrochemical Science

ISSN

1452-3981

e-ISSN

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Svazek periodika

7

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

RS - Srbská republika

Počet stran výsledku

16

Strana od-do

4286-4301

Kód UT WoS článku

000305267000036

EID výsledku v databázi Scopus

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