A rapid method for the sarcosine detection using pseudo-peroxidase activity of superparamagnetic iron oxide nanoparticles (SPIONS)

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F18%3A43877005" target="_blank" >RIV/62157124:16370/18:43877005 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

A rapid method for the sarcosine detection using pseudo-peroxidase activity of superparamagnetic iron oxide nanoparticles (SPIONS)

Popis výsledku v původním jazyce

Sarcosine is an amino acid that is formed by methylation of glycine and is present in trace amounts in the body. Increased sarcosine concentrations in blood plasma and urine are manifested in sarcosinemia and in some other diseases such as prostate cancer. For this purpose, sarcosine detection using the nanomedicine approach was proposed. In this study, we have prepared superparamagnetic iron oxide nanoparticles (SPIONs) with different modified surface area. Gold nanoparticles (AuNPs) were modified by chitosan (CS), and sarcosine oxidase (SOX). SPIONs without any modification were taken as controls. The proposed detection system allows to analyse sarcosine as a potential prostate cancer marker at micromolar concentrations and to monitor changes in its levels.

Název v anglickém jazyce

A rapid method for the sarcosine detection using pseudo-peroxidase activity of superparamagnetic iron oxide nanoparticles (SPIONS)

Popis výsledku anglicky

Sarcosine is an amino acid that is formed by methylation of glycine and is present in trace amounts in the body. Increased sarcosine concentrations in blood plasma and urine are manifested in sarcosinemia and in some other diseases such as prostate cancer. For this purpose, sarcosine detection using the nanomedicine approach was proposed. In this study, we have prepared superparamagnetic iron oxide nanoparticles (SPIONs) with different modified surface area. Gold nanoparticles (AuNPs) were modified by chitosan (CS), and sarcosine oxidase (SOX). SPIONs without any modification were taken as controls. The proposed detection system allows to analyse sarcosine as a potential prostate cancer marker at micromolar concentrations and to monitor changes in its levels.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

30404 - Biomaterials (as related to medical implants, devices, sensors)

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů