Adipophilin (ADRP/ADPH/PLIN2): Variability in Exonic Regions and Secretion of Adipophilin into Breast Milk

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F12%3A00060618" target="_blank" >RIV/00216224:14110/12:00060618 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Adipophilin (ADRP/ADPH/PLIN2): Variability in Exonic Regions and Secretion of Adipophilin into Breast Milk

Popis výsledku v původním jazyce

Introduction: Adipophilin (ADRP/ADPH/PLIN2), a member of the perilipin (PAT) family of lipid droplet proteins, is believed to play a crucial role in both formation and secretion of milk lipids in mammals. The aim of our study was to determine whether adipophilin is secreted into human breast milk and to associate adipophilin levels in breast milk with the exonic variations of the adipophilin gene. Material and methods: The total of 20 pregnant women with physiological pregnancy, originating from the Caucasian Central-European population, were enrolled into the study and serum-milk sample duos were collected at the time of birth and at the days 1-3, 12-14, 28-30, 88-90 and 178-180 postpartum and investigated using ELISA-based methodology. The exons 3-7of the PLIN2 gene were directly sequenced.Results: Adipophilin was constantly secreted into breast milk during the whole period of the study. The maternal serum circulating levels were extremely low (&lt;0.

Název v anglickém jazyce

Adipophilin (ADRP/ADPH/PLIN2): Variability in Exonic Regions and Secretion of Adipophilin into Breast Milk

Popis výsledku anglicky

Introduction: Adipophilin (ADRP/ADPH/PLIN2), a member of the perilipin (PAT) family of lipid droplet proteins, is believed to play a crucial role in both formation and secretion of milk lipids in mammals. The aim of our study was to determine whether adipophilin is secreted into human breast milk and to associate adipophilin levels in breast milk with the exonic variations of the adipophilin gene. Material and methods: The total of 20 pregnant women with physiological pregnancy, originating from the Caucasian Central-European population, were enrolled into the study and serum-milk sample duos were collected at the time of birth and at the days 1-3, 12-14, 28-30, 88-90 and 178-180 postpartum and investigated using ELISA-based methodology. The exons 3-7of the PLIN2 gene were directly sequenced.Results: Adipophilin was constantly secreted into breast milk during the whole period of the study. The maternal serum circulating levels were extremely low (&lt;0.

Druh

O - Ostatní výsledky

CEP obor

FK - Gynekologie a porodnictví

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů