Vistafin: Association with Genetic Variability in Vistafin (PBEF) Gene, Anthropometric Parameters and Dietary Composition in Obese and Non-Obese Central-European Population

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F12%3A00060619" target="_blank" >RIV/00216224:14110/12:00060619 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Vistafin: Association with Genetic Variability in Vistafin (PBEF) Gene, Anthropometric Parameters and Dietary Composition in Obese and Non-Obese Central-European Population

Popis výsledku v původním jazyce

strong insulin-mimetic activity. However, nothing is known about whether visfatin is related to specific nutritional behavior which may result in obesity development. This is the first study focusing on genetic variability of the visfatin gene and its association with circulating visfatin, anthropometric parameters and dietary composition. We analyzed a total of 6 exons and adjacent non-coding regions of the PBEF gene in 20 extremely obese Czech individuals using direct sequencing and a frequency of rs2302559 was established in the validation cohort of another 605 individuals with completed 7-day food records and complex anthropometric measurements. Plasma levels of visfatin, leptin and leptin-receptor were measured in all sequenced individuals and inpart of the validation cohort. Three common polymorphisms were identified, two in non-coding regions (rs78411774 A/C, rs71564769 A/C) and one synonymous SNP in exon 7 (rs2302559 A/G).

Název v anglickém jazyce

Vistafin: Association with Genetic Variability in Vistafin (PBEF) Gene, Anthropometric Parameters and Dietary Composition in Obese and Non-Obese Central-European Population

Popis výsledku anglicky

strong insulin-mimetic activity. However, nothing is known about whether visfatin is related to specific nutritional behavior which may result in obesity development. This is the first study focusing on genetic variability of the visfatin gene and its association with circulating visfatin, anthropometric parameters and dietary composition. We analyzed a total of 6 exons and adjacent non-coding regions of the PBEF gene in 20 extremely obese Czech individuals using direct sequencing and a frequency of rs2302559 was established in the validation cohort of another 605 individuals with completed 7-day food records and complex anthropometric measurements. Plasma levels of visfatin, leptin and leptin-receptor were measured in all sequenced individuals and inpart of the validation cohort. Three common polymorphisms were identified, two in non-coding regions (rs78411774 A/C, rs71564769 A/C) and one synonymous SNP in exon 7 (rs2302559 A/G).

Druh

O - Ostatní výsledky

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů