Determination of 8-hydroxy-2´-deoxyguanosine in urine by high-performance liquid chromatography

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F12%3A00062934" target="_blank" >RIV/00216224:14110/12:00062934 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Determination of 8-hydroxy-2´-deoxyguanosine in urine by high-performance liquid chromatography

Popis výsledku v původním jazyce

Reactive oxygen species (ROS) are continuously formed in cell metabolism. Under pathological conditions, there is imbalance between prooxidative and antioxidative processes. ROS cause oxidative damage to cell macromolecules ? proteins as well as lipids,but damage on DNA possesses the biggest importance. In our study, the method for analysis of urinary 8OHdG by HPLC was developed. The method is based on SPE purification follows by HPLC with coulometric detection.

Název v anglickém jazyce

Determination of 8-hydroxy-2´-deoxyguanosine in urine by high-performance liquid chromatography

Popis výsledku anglicky

Reactive oxygen species (ROS) are continuously formed in cell metabolism. Under pathological conditions, there is imbalance between prooxidative and antioxidative processes. ROS cause oxidative damage to cell macromolecules ? proteins as well as lipids,but damage on DNA possesses the biggest importance. In our study, the method for analysis of urinary 8OHdG by HPLC was developed. The method is based on SPE purification follows by HPLC with coulometric detection.

Druh

O - Ostatní výsledky

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů