Efficient use of basic biochemical methods to prove the presence of monoclonal protein in the clinical diagnosis of malignant monoclonal gammopathy
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F13%3A00068551" target="_blank" >RIV/00216224:14110/13:00068551 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/65269705:_____/13:#0002102
Výsledek na webu
<a href="http://dx.doi.org/10.1515/cclm-2013-0090" target="_blank" >http://dx.doi.org/10.1515/cclm-2013-0090</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1515/cclm-2013-0090" target="_blank" >10.1515/cclm-2013-0090</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Efficient use of basic biochemical methods to prove the presence of monoclonal protein in the clinical diagnosis of malignant monoclonal gammopathy
Popis výsledku v původním jazyce
Background: This retrospective study evaluates the diagnostic sensitivity of biochemistry methods for the clinical diagnosis of malignant monoclonal gammopathy. In patients with renal insufficiency, renal reference interval as well as standard referenceinterval is used for evaluating the ratio of free light chains. Methods: We examined samples in 281 patients who were diagnosed with malignant monoclonal gammopathy. The samples were taken at baseline, prior to treatment. Serum and urine protein electrophoresis, serum and urine immunofixation electrophoresis (SIFE+UIFE) and levels of free light chains in serum (FLC) were investigated. Results: Combination of methods with the highest diagnostic sensitivity is the use of maximal number of tests (SIFE+ UIFE + FLC), which identified 98.6% of patients. The achieved results do not statistically significantly differ from the procedure recommended by the International Myeloma Working Group (IMWG) which omitts the urine testing (SIFE + FLC) and
Název v anglickém jazyce
Efficient use of basic biochemical methods to prove the presence of monoclonal protein in the clinical diagnosis of malignant monoclonal gammopathy
Popis výsledku anglicky
Background: This retrospective study evaluates the diagnostic sensitivity of biochemistry methods for the clinical diagnosis of malignant monoclonal gammopathy. In patients with renal insufficiency, renal reference interval as well as standard referenceinterval is used for evaluating the ratio of free light chains. Methods: We examined samples in 281 patients who were diagnosed with malignant monoclonal gammopathy. The samples were taken at baseline, prior to treatment. Serum and urine protein electrophoresis, serum and urine immunofixation electrophoresis (SIFE+UIFE) and levels of free light chains in serum (FLC) were investigated. Results: Combination of methods with the highest diagnostic sensitivity is the use of maximal number of tests (SIFE+ UIFE + FLC), which identified 98.6% of patients. The achieved results do not statistically significantly differ from the procedure recommended by the International Myeloma Working Group (IMWG) which omitts the urine testing (SIFE + FLC) and
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
CE - Biochemie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2013
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Clinical Chemistry and Laboratory Medicine
ISSN
1434-6621
e-ISSN
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Svazek periodika
51
Číslo periodika v rámci svazku
10
Stát vydavatele periodika
DE - Spolková republika Německo
Počet stran výsledku
3
Strana od-do
"e243"-"e245"
Kód UT WoS článku
000324921300008
EID výsledku v databázi Scopus
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