Statistical Analysis of Dose-Volume Profiles and its Implication for Radiation Therapy Planning in Prostate Carcinoma

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F13%3A00068772" target="_blank" >RIV/00216224:14110/13:00068772 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15110/13:33147992 RIV/00216275:25520/14:39898693

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.ijrobp.2013.03.018" target="_blank" >http://dx.doi.org/10.1016/j.ijrobp.2013.03.018</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ijrobp.2013.03.018" target="_blank" >10.1016/j.ijrobp.2013.03.018</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Statistical Analysis of Dose-Volume Profiles and its Implication for Radiation Therapy Planning in Prostate Carcinoma

Popis výsledku v původním jazyce

Purpose: The study aimed to analyze the dose-volume profiles of 3-dimensional radiation therapy (3D-CRT) and intensity modulated RT (IMRT) in the treatment of prostate carcinoma and to specify the profiles responsible for the development of gastrointestinal (GI) toxicity. Methods and Materials: In the period 1997 to 2007, 483 patients with prostate carcinoma in stage T1-3 N0 (pN0) M0 were treated with definitive RT. Two groups of patients were defined for the analysis: the 3D-CRT group (n=305 patients)and the IMRT group (n=178 patients). In the entire cohort of 483 patients, the median follow-up time reached 4.4 years (range, 2.0-11.7 years). The cumulative absolute and relative volumes of irradiated rectum exposed to a given dose (area under the dose-volume curve, AUC) were estimated. The receiver operating characteristic analysis was then used to search for the optimal dose and volume cutoff points with the potential to distinguish patients with enhanced or escalated toxicity.

Název v anglickém jazyce

Statistical Analysis of Dose-Volume Profiles and its Implication for Radiation Therapy Planning in Prostate Carcinoma

Popis výsledku anglicky

Purpose: The study aimed to analyze the dose-volume profiles of 3-dimensional radiation therapy (3D-CRT) and intensity modulated RT (IMRT) in the treatment of prostate carcinoma and to specify the profiles responsible for the development of gastrointestinal (GI) toxicity. Methods and Materials: In the period 1997 to 2007, 483 patients with prostate carcinoma in stage T1-3 N0 (pN0) M0 were treated with definitive RT. Two groups of patients were defined for the analysis: the 3D-CRT group (n=305 patients)and the IMRT group (n=178 patients). In the entire cohort of 483 patients, the median follow-up time reached 4.4 years (range, 2.0-11.7 years). The cumulative absolute and relative volumes of irradiated rectum exposed to a given dose (area under the dose-volume curve, AUC) were estimated. The receiver operating characteristic analysis was then used to search for the optimal dose and volume cutoff points with the potential to distinguish patients with enhanced or escalated toxicity.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

BB - Aplikovaná statistika, operační výzkum

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Radiation Oncology Biology Physics

ISSN

0360-3016

e-ISSN

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Svazek periodika

86

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

769-776

Kód UT WoS článku

000320590200035

EID výsledku v databázi Scopus

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