Expression, function and regulation of Evi-1 during embryonic avian development

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F13%3A00069046" target="_blank" >RIV/00216224:14110/13:00069046 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68081766:_____/13:00394981 RIV/67985904:_____/13:00394981 RIV/62157124:16170/13:43871904

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.gep.2013.06.002" target="_blank" >http://dx.doi.org/10.1016/j.gep.2013.06.002</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.gep.2013.06.002" target="_blank" >10.1016/j.gep.2013.06.002</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Expression, function and regulation of Evi-1 during embryonic avian development

Popis výsledku v původním jazyce

Ecotropical viral integration site 1 (Evi-1) is a transcription factor essential for vascularisation and cell proliferation during embryonic development. The chimeric transcription factor AML1-EVI-1 is activated in leukaemia where it plays a role as a differentiation block and stimulator of proliferation. Here, we cloned chicken Evi-1 and analysed its expression during embryonic development. There was early expression in the pharyngeal arches, in the brain and intermediate mesoderm of chicken embryos atstage 15. Later at stage 20, Evi-1 mesenchymal expression was concentrated in the second pharyngeal arch, and weaker expression was found in the mandibular and maxillary prominences. Facial expression decreased in intensity during development. Evi-1 expression in the limb was also limited to the mesenchyme with the most prominent expression in the anterior margin. Evi-1 was not detectable in the posterior limb bud.

Název v anglickém jazyce

Expression, function and regulation of Evi-1 during embryonic avian development

Popis výsledku anglicky

Ecotropical viral integration site 1 (Evi-1) is a transcription factor essential for vascularisation and cell proliferation during embryonic development. The chimeric transcription factor AML1-EVI-1 is activated in leukaemia where it plays a role as a differentiation block and stimulator of proliferation. Here, we cloned chicken Evi-1 and analysed its expression during embryonic development. There was early expression in the pharyngeal arches, in the brain and intermediate mesoderm of chicken embryos atstage 15. Later at stage 20, Evi-1 mesenchymal expression was concentrated in the second pharyngeal arch, and weaker expression was found in the mandibular and maxillary prominences. Facial expression decreased in intensity during development. Evi-1 expression in the limb was also limited to the mesenchyme with the most prominent expression in the anterior margin. Evi-1 was not detectable in the posterior limb bud.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

<a href="/cs/project/GA304%2F09%2F0725" target="_blank" >GA304/09/0725: Signální dráhy podílející se na identitě čelistí</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Gene Expression Patterns

ISSN

1567-133X

e-ISSN

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Svazek periodika

13

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

11

Strana od-do

343-353

Kód UT WoS článku

000328595100008

EID výsledku v databázi Scopus

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