Strong negative interference of ethamsylate (Dicynone (R)) in serum creatinine quantification via enzymatic assay using Trinder reaction

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F13%3A00069727" target="_blank" >RIV/00216224:14110/13:00069727 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/65269705:_____/13:#0002079

Výsledek na webu

<a href="http://dx.doi.org/10.3109/00365513.2013.794300" target="_blank" >http://dx.doi.org/10.3109/00365513.2013.794300</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3109/00365513.2013.794300" target="_blank" >10.3109/00365513.2013.794300</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Strong negative interference of ethamsylate (Dicynone (R)) in serum creatinine quantification via enzymatic assay using Trinder reaction

Popis výsledku v původním jazyce

Background. With discrepancies encountered as early as the verification of enzymatic method for quantification of serum creatinine, our research pointed to a later confirmed interference caused by a compound called ethamsylate present in the commonly used antihemorrhagic drug Dicynone. Methods. We measured concentrations of creatinine of 10 patients with blood taken before and 15 minutes after the intravenous administration of a 500 mg dose of Dicynone. The creatinine concentration was determined usingJaffe method and enzymatic method that utilize Trinder reaction (Roche) in analyzer Cobas c 501 (Roche AG, Basel, Switzerland). We also monitored concentration of blood creatinine in three patients before and 15 minutes after application of Dicynone (500mg i.v.) and in the following 6th, 12th, 18th, and 24th hours. Results. We discovered a significant negative bias in creatinine results using enzymatic assay with Trinder reaction in blood taken 15 min after i.v.

Název v anglickém jazyce

Strong negative interference of ethamsylate (Dicynone (R)) in serum creatinine quantification via enzymatic assay using Trinder reaction

Popis výsledku anglicky

Background. With discrepancies encountered as early as the verification of enzymatic method for quantification of serum creatinine, our research pointed to a later confirmed interference caused by a compound called ethamsylate present in the commonly used antihemorrhagic drug Dicynone. Methods. We measured concentrations of creatinine of 10 patients with blood taken before and 15 minutes after the intravenous administration of a 500 mg dose of Dicynone. The creatinine concentration was determined usingJaffe method and enzymatic method that utilize Trinder reaction (Roche) in analyzer Cobas c 501 (Roche AG, Basel, Switzerland). We also monitored concentration of blood creatinine in three patients before and 15 minutes after application of Dicynone (500mg i.v.) and in the following 6th, 12th, 18th, and 24th hours. Results. We discovered a significant negative bias in creatinine results using enzymatic assay with Trinder reaction in blood taken 15 min after i.v.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

ISSN

0036-5513

e-ISSN

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Svazek periodika

73

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

3

Strana od-do

449-451

Kód UT WoS článku

000323106700014

EID výsledku v databázi Scopus

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