Ethamsylate (Dicynone?) Interference in Determination of Serum Creatinine, Uric Acid, Triglycerides, and Cholesterol in Assays Involving the Trinder Reaction; In Vivo and In Vitro

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F14%3A00076245" target="_blank" >RIV/00216224:14110/14:00076245 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.7754/Clin.Lab.2013.130902" target="_blank" >http://dx.doi.org/10.7754/Clin.Lab.2013.130902</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.7754/Clin.Lab.2013.130902" target="_blank" >10.7754/Clin.Lab.2013.130902</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Ethamsylate (Dicynone?) Interference in Determination of Serum Creatinine, Uric Acid, Triglycerides, and Cholesterol in Assays Involving the Trinder Reaction; In Vivo and In Vitro

Popis výsledku v původním jazyce

Background: The aim of our research was the quantification of interfering properties of the haemostatic drug Dicynone? (ethamsylate) in serum creatinine, uric acid, cholesterol, and triglyceride assays using the Trinder reaction. Methods: Blood from patients was collected before and 15 minutes after administration of 500 mg Dicynone? dose i.v. and the above mentioned analytes were quantified using Roche assays (Cobas 8000). In our in vitro experiment, we measured concentrations of the analytes in pooledserum aliquots with final concentrations of Dicynone? additions 0, 30, 60, 150, and 300 mg/L. Aliquots with 60 mg/L Dicynone? were also measured at 2, 6, and 8 hours after initial measurement when stored in 22°C and 4°C for comparison. Results: Concentrations of the measured analytes in samples from patients administered with a 500 mg dose of Dicynone? were lower in all cases (n = 10) when compared to values in samples taken immediately before treatment.

Název v anglickém jazyce

Ethamsylate (Dicynone?) Interference in Determination of Serum Creatinine, Uric Acid, Triglycerides, and Cholesterol in Assays Involving the Trinder Reaction; In Vivo and In Vitro

Popis výsledku anglicky

Background: The aim of our research was the quantification of interfering properties of the haemostatic drug Dicynone? (ethamsylate) in serum creatinine, uric acid, cholesterol, and triglyceride assays using the Trinder reaction. Methods: Blood from patients was collected before and 15 minutes after administration of 500 mg Dicynone? dose i.v. and the above mentioned analytes were quantified using Roche assays (Cobas 8000). In our in vitro experiment, we measured concentrations of the analytes in pooledserum aliquots with final concentrations of Dicynone? additions 0, 30, 60, 150, and 300 mg/L. Aliquots with 60 mg/L Dicynone? were also measured at 2, 6, and 8 hours after initial measurement when stored in 22°C and 4°C for comparison. Results: Concentrations of the measured analytes in samples from patients administered with a 500 mg dose of Dicynone? were lower in all cases (n = 10) when compared to values in samples taken immediately before treatment.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical Laboratory

ISSN

1433-6510

e-ISSN

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Svazek periodika

60

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

4

Strana od-do

1373-1376

Kód UT WoS článku

000342857800015

EID výsledku v databázi Scopus

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