EFFECT OF ION CONCENTRATION CHANGES IN T-TUBULES ON INTRACELLULAR SIGNALS CONTROLLING MECHANICAL ACTIVITY IN A MODEL OF HUMAN VENTRICULAR CARDIOMYOCYTE

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F13%3A00076830" target="_blank" >RIV/00216224:14110/13:00076830 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61388998:_____/13:00437443

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

EFFECT OF ION CONCENTRATION CHANGES IN T-TUBULES ON INTRACELLULAR SIGNALS CONTROLLING MECHANICAL ACTIVITY IN A MODEL OF HUMAN VENTRICULAR CARDIOMYOCYTE

Popis výsledku v původním jazyce

The transverse (t-) tubular system serves to bring electrical signals deep inside the muscle cells to control mechanical responses. Our preliminary mathematical model of human ventricular cardiomyocyte incorporating t-tubular system [1] was improved by introducing description of latest experimental data related to morphology of human t-tubules and to specific properties of ionic currents. To describe the ion diffusion within t-tubular lumen, we partitioned the t-tubule compartment into nine concentric cylindrical segments. Using the model, we studied the effect of activity-induced concentration changes in the t-tubules on Ca2+ entry into the cell and the intracellular Ca2+ transients controlling the strength of cellular contraction. The values of somecrucial parameters, unknown in human cardiomyocytes to date, were regarded as independent variables.

Název v anglickém jazyce

EFFECT OF ION CONCENTRATION CHANGES IN T-TUBULES ON INTRACELLULAR SIGNALS CONTROLLING MECHANICAL ACTIVITY IN A MODEL OF HUMAN VENTRICULAR CARDIOMYOCYTE

Popis výsledku anglicky

The transverse (t-) tubular system serves to bring electrical signals deep inside the muscle cells to control mechanical responses. Our preliminary mathematical model of human ventricular cardiomyocyte incorporating t-tubular system [1] was improved by introducing description of latest experimental data related to morphology of human t-tubules and to specific properties of ionic currents. To describe the ion diffusion within t-tubular lumen, we partitioned the t-tubule compartment into nine concentric cylindrical segments. Using the model, we studied the effect of activity-induced concentration changes in the t-tubules on Ca2+ entry into the cell and the intracellular Ca2+ transients controlling the strength of cellular contraction. The values of somecrucial parameters, unknown in human cardiomyocytes to date, were regarded as independent variables.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

ED - Fyziologie

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Engineering mechanics

ISSN

1802-1484

e-ISSN

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Svazek periodika

20

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

10

Strana od-do

481-490

Kód UT WoS článku

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EID výsledku v databázi Scopus

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