ROLE OF SUBMEMBRANE SPACES IN THE CONTROL OF TRANSMEMBRANE ION FLUX AND CELLULAR INOTROPIC STATE IN A MODEL OF HUMAN VENTRICULAR CARDIOMYOCYTE

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F24%3A00139960" target="_blank" >RIV/00216224:14110/24:00139960 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.engmech.cz/improc/2024/230.pdf" target="_blank" >https://www.engmech.cz/improc/2024/230.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

ROLE OF SUBMEMBRANE SPACES IN THE CONTROL OF TRANSMEMBRANE ION FLUX AND CELLULAR INOTROPIC STATE IN A MODEL OF HUMAN VENTRICULAR CARDIOMYOCYTE

Popis výsledku v původním jazyce

We have recently developed a model of human ventricular cardiomyocyte incorporating the t-tubular and surface submembrane spaces and restricted ion exchange between these spaces and cytosol. After incorporating the experimental finding that majority of Na+ -Ca2+ exchanger proteins are located at the t-tubular membrane of human ventricular cardiomyocytes, we explored the consequences of ion concentration changes in the submembrane spaces on the electrophysiological activity of these cells. Consistently with the experimental and modelling studies published so far, our model predicts an increased Ca2+ extrusion during the action potential. However, our model also predicts a significant reduction of Ca2+ extrusion throughout the diastole, which can ultimately lead to an increase of cellular inotropy.

Název v anglickém jazyce

ROLE OF SUBMEMBRANE SPACES IN THE CONTROL OF TRANSMEMBRANE ION FLUX AND CELLULAR INOTROPIC STATE IN A MODEL OF HUMAN VENTRICULAR CARDIOMYOCYTE

Popis výsledku anglicky

We have recently developed a model of human ventricular cardiomyocyte incorporating the t-tubular and surface submembrane spaces and restricted ion exchange between these spaces and cytosol. After incorporating the experimental finding that majority of Na+ -Ca2+ exchanger proteins are located at the t-tubular membrane of human ventricular cardiomyocytes, we explored the consequences of ion concentration changes in the submembrane spaces on the electrophysiological activity of these cells. Consistently with the experimental and modelling studies published so far, our model predicts an increased Ca2+ extrusion during the action potential. However, our model also predicts a significant reduction of Ca2+ extrusion throughout the diastole, which can ultimately lead to an increase of cellular inotropy.

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

<a href="/cs/project/NU22-02-00348" target="_blank" >NU22-02-00348: Funkční hodnocení genetických variant u případů klinicky „skutečné“ idiopatické fibrilace komor: in vitro a in silico modelování s cílem odhalit arytmogenní mechanismus</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

ENGINEERING MECHANICS: 30th INTERNATIONAL CONFERENCE May 14 – 16, 2024, Milovy, Czech Republic

ISBN

9788021462359

ISSN

1805-8248

e-ISSN

1805-8256

Počet stran výsledku

4

Strana od-do

230-233

Název nakladatele

Institute of Thermomechanics, Academy of Sciences of the Czech Republic

Místo vydání

Prague

Místo konání akce

Milovy

Datum konání akce

14. 5. 2024

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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