Period3 VNTR polymorphism influences the time-of-day pain onset of acute myocardial infarction with ST elevation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F14%3A00076387" target="_blank" >RIV/00216224:14110/14:00076387 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00159816:_____/14:00061107 RIV/65269705:_____/14:00061107

Výsledek na webu

<a href="http://dx.doi.org/10.3109/07420528.2014.921790" target="_blank" >http://dx.doi.org/10.3109/07420528.2014.921790</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3109/07420528.2014.921790" target="_blank" >10.3109/07420528.2014.921790</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Period3 VNTR polymorphism influences the time-of-day pain onset of acute myocardial infarction with ST elevation

Popis výsledku v původním jazyce

It is well established that the incidence and infarct size in acute myocardial infarction (AMI) is subject to circadian variations. At the molecular level, circadian clocks in distinct cells, including cardiomyocytes, generate 24-h cycles of biochemicalprocesses. Possible imbalance or impairment in the cell clock mechanism may alter the cardiac metabolism and function and increase the susceptibility of cardiovascular diseases. One of the key components of the human clock system PERIOD3 (PER3) has beenrecently demonstrated to affect circadian expression of various genes in different tissues, including the heart. The variable number tandem repeat (VNTR) polymorphism (rs57875989) in gene Period3 (Per3) is related to multiple phenotypic parameters, including diurnal preference, sleep homeostasis, infection and cancer. The aim of our study was to investigate the effect of this polymorphism in AMI with ST elevation (STEMI).

Název v anglickém jazyce

Period3 VNTR polymorphism influences the time-of-day pain onset of acute myocardial infarction with ST elevation

Popis výsledku anglicky

It is well established that the incidence and infarct size in acute myocardial infarction (AMI) is subject to circadian variations. At the molecular level, circadian clocks in distinct cells, including cardiomyocytes, generate 24-h cycles of biochemicalprocesses. Possible imbalance or impairment in the cell clock mechanism may alter the cardiac metabolism and function and increase the susceptibility of cardiovascular diseases. One of the key components of the human clock system PERIOD3 (PER3) has beenrecently demonstrated to affect circadian expression of various genes in different tissues, including the heart. The variable number tandem repeat (VNTR) polymorphism (rs57875989) in gene Period3 (Per3) is related to multiple phenotypic parameters, including diurnal preference, sleep homeostasis, infection and cancer. The aim of our study was to investigate the effect of this polymorphism in AMI with ST elevation (STEMI).

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

ED - Fyziologie

OECD FORD obor

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Projekt

<a href="/cs/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: Fakultní nemocnice u sv. Anny v Brně - Mezinárodní centrum klinického výzkumu (FNUSA - ICRC)</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chronobiology International

ISSN

0742-0528

e-ISSN

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Svazek periodika

31

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

13

Strana od-do

878-890

Kód UT WoS článku

000341754000002

EID výsledku v databázi Scopus

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