Lack of adenosine A(3) receptors causes defects in mouse peripheral blood parameters

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F14%3A00077295" target="_blank" >RIV/00216224:14110/14:00077295 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68081707:_____/14:00435165

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s11302-014-9412-9" target="_blank" >http://dx.doi.org/10.1007/s11302-014-9412-9</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s11302-014-9412-9" target="_blank" >10.1007/s11302-014-9412-9</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Lack of adenosine A(3) receptors causes defects in mouse peripheral blood parameters

Popis výsledku v původním jazyce

The role of the adenosine A(3) receptor in hematopoiesis was studied using adenosine A(3) receptor knockout (A(3)AR KO) mice. Hematological parameters of peripheral blood and femoral bone marrow of irradiated and untreated A(3)AR KO mice and their wild-type (WT) counterparts were investigated. Irradiation of the mice served as a defined hematopoiesis-damaging means enabling us to evaluate contingent differences in the pattern of experimentally induced hematopoietic suppression between the A(3)AR KO miceand WT mice. Defects were observed in the counts and/or functional parameters of blood cells in the A(3)AR KO mice. These defects include statistically significantly lower values of blood neutrophil and monocyte counts, as well as those of mean erythrocyte volume, mean erythrocyte hemoglobin, blood platelet counts, mean platelet volume, and plateletcrit, and can be considered to bear evidence of the lack of a positive role played by the adenosine A(3) receptor in the hematopoietic syste

Název v anglickém jazyce

Lack of adenosine A(3) receptors causes defects in mouse peripheral blood parameters

Popis výsledku anglicky

The role of the adenosine A(3) receptor in hematopoiesis was studied using adenosine A(3) receptor knockout (A(3)AR KO) mice. Hematological parameters of peripheral blood and femoral bone marrow of irradiated and untreated A(3)AR KO mice and their wild-type (WT) counterparts were investigated. Irradiation of the mice served as a defined hematopoiesis-damaging means enabling us to evaluate contingent differences in the pattern of experimentally induced hematopoietic suppression between the A(3)AR KO miceand WT mice. Defects were observed in the counts and/or functional parameters of blood cells in the A(3)AR KO mice. These defects include statistically significantly lower values of blood neutrophil and monocyte counts, as well as those of mean erythrocyte volume, mean erythrocyte hemoglobin, blood platelet counts, mean platelet volume, and plateletcrit, and can be considered to bear evidence of the lack of a positive role played by the adenosine A(3) receptor in the hematopoietic syste

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

<a href="/cs/project/GAP303%2F11%2F0128" target="_blank" >GAP303/11/0128: Úloha signalizace adenosinovými A3 receptory v regulaci krvetvorby: Znalosti získané z myší s knockoutovanými A3 receptory</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Purinergic signalling

ISSN

1573-9538

e-ISSN

—

Svazek periodika

10

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

6

Strana od-do

509-514

Kód UT WoS článku

000341772500010

EID výsledku v databázi Scopus

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