Enhanced survival of lethally irradiated adenosine A(3) receptor knockout mice. A role for hematopoietic growth factors?
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F15%3A00082993" target="_blank" >RIV/00216224:14110/15:00082993 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/68081707:_____/15:00446328
Výsledek na webu
<a href="http://dx.doi.org/10.1007/s11302-014-9432-5" target="_blank" >http://dx.doi.org/10.1007/s11302-014-9432-5</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11302-014-9432-5" target="_blank" >10.1007/s11302-014-9432-5</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Enhanced survival of lethally irradiated adenosine A(3) receptor knockout mice. A role for hematopoietic growth factors?
Popis výsledku v původním jazyce
Adenosine A(3) receptor knockout (A(3)AR KO) mice and their wild-type (WT) counterparts were compared from the point of view of their abilities to survive exposures to lethal doses of gamma-radiation belonging to the range of radiation doses inducing thebone marrow acute radiation syndrome. Parameters of cumulative 30-day survival (experiment using a midlethal radiation dose) or cumulative 11-day survival (experiment using an absolutely lethal radiation dose), and of mean survival time were evaluated.The values of A(3)AR KO mice always reflected their higher survival in comparison with WT ones, the P values being above the limit for statistical significance after the midlethal radiation dose and standing for statistical significance after the absolutely lethal radiation dose. This finding was considered surprising, taking into account the previously obtained findings on defects in numbers and functional properties of peripheral blood cells in A(3)AR KO mice.
Název v anglickém jazyce
Enhanced survival of lethally irradiated adenosine A(3) receptor knockout mice. A role for hematopoietic growth factors?
Popis výsledku anglicky
Adenosine A(3) receptor knockout (A(3)AR KO) mice and their wild-type (WT) counterparts were compared from the point of view of their abilities to survive exposures to lethal doses of gamma-radiation belonging to the range of radiation doses inducing thebone marrow acute radiation syndrome. Parameters of cumulative 30-day survival (experiment using a midlethal radiation dose) or cumulative 11-day survival (experiment using an absolutely lethal radiation dose), and of mean survival time were evaluated.The values of A(3)AR KO mice always reflected their higher survival in comparison with WT ones, the P values being above the limit for statistical significance after the midlethal radiation dose and standing for statistical significance after the absolutely lethal radiation dose. This finding was considered surprising, taking into account the previously obtained findings on defects in numbers and functional properties of peripheral blood cells in A(3)AR KO mice.
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
CE - Biochemie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2015
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Purinergic signalling
ISSN
1573-9538
e-ISSN
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Svazek periodika
11
Číslo periodika v rámci svazku
1
Stát vydavatele periodika
NL - Nizozemsko
Počet stran výsledku
7
Strana od-do
79-85
Kód UT WoS článku
000350883100004
EID výsledku v databázi Scopus
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