Why and how to spare the hippocampus during brain radiotherapy: the developing role of hippocampal avoidance in cranial radiotherapy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F14%3A00078354" target="_blank" >RIV/00216224:14110/14:00078354 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00159816:_____/14:00061130

Výsledek na webu

<a href="http://dx.doi.org/10.1186/1748-717X-9-139" target="_blank" >http://dx.doi.org/10.1186/1748-717X-9-139</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/1748-717X-9-139" target="_blank" >10.1186/1748-717X-9-139</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Why and how to spare the hippocampus during brain radiotherapy: the developing role of hippocampal avoidance in cranial radiotherapy

Popis výsledku v původním jazyce

The goal of this review is to summarize the rationale for and feasibility of hippocampal sparing techniques during brain irradiation. Radiotherapy is the most effective non-surgical treatment of brain tumors and with the improvement in overall survival for these patients over the last few decades, there is an effort to minimize potential adverse effects leading to possible worsening in quality of life, especially worsening of neurocognitive function. The hippocampus and associated limbic system have long been known to be important in memory formation and pre-clinical models show loss of hippocampal stem cells with radiation as well as changes in architecture and function of mature neurons. Cognitive outcomes in clinical studies are beginning to provideevidence of cognitive effects associated with hippocampal dose and the cognitive benefits of hippocampal sparing.

Název v anglickém jazyce

Why and how to spare the hippocampus during brain radiotherapy: the developing role of hippocampal avoidance in cranial radiotherapy

Popis výsledku anglicky

The goal of this review is to summarize the rationale for and feasibility of hippocampal sparing techniques during brain irradiation. Radiotherapy is the most effective non-surgical treatment of brain tumors and with the improvement in overall survival for these patients over the last few decades, there is an effort to minimize potential adverse effects leading to possible worsening in quality of life, especially worsening of neurocognitive function. The hippocampus and associated limbic system have long been known to be important in memory formation and pre-clinical models show loss of hippocampal stem cells with radiation as well as changes in architecture and function of mature neurons. Cognitive outcomes in clinical studies are beginning to provideevidence of cognitive effects associated with hippocampal dose and the cognitive benefits of hippocampal sparing.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Radiation Oncology

ISSN

1748-717X

e-ISSN

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Svazek periodika

9

Číslo periodika v rámci svazku

139

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

10

Strana od-do

1-10

Kód UT WoS článku

000338674700001

EID výsledku v databázi Scopus

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