The Effect of Voltage Sensitive Dye di-4-ANEPPS on the RT/RR Coupling in Rabbit Isolated Heart

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F15%3A00081553" target="_blank" >RIV/00216224:14110/15:00081553 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The Effect of Voltage Sensitive Dye di-4-ANEPPS on the RT/RR Coupling in Rabbit Isolated Heart

Popis výsledku v původním jazyce

Voltage sensitive dye (VSD) di-4-ANEPPS is ordinary used for optical measurement of action potential in experimental cardiology. In this work, the effect of the dye on the RT/RR coupling measured in electrograms (EG) recorded on rabbit isolated hearts was studied. The results were compared with the control experiments without VSD administration. The comparison was performed in preparation stage of the experiment that consisted of three phases: stabilization (S), VSD loading (L), and washout (W). The median and interquartile range (Q0.75-Q0.25) of the difference in RR, QT and RT/RR between the beginning and the end of the phases were computed and compared between the both groups.(RT/RR), in S, L and W, was -0.095, 0.061; -0.093, 0.043; -0.027, 0.039 indi-4-ANEPPS-treated group and -0.127, 0.071; 0.006, 0.016; -0.001, 0.025 in control group. The significant difference (P&lt;0.01) was found between two groups in L phase. Additionally, there was the significant difference in RR [ms] which

Název v anglickém jazyce

The Effect of Voltage Sensitive Dye di-4-ANEPPS on the RT/RR Coupling in Rabbit Isolated Heart

Popis výsledku anglicky

Voltage sensitive dye (VSD) di-4-ANEPPS is ordinary used for optical measurement of action potential in experimental cardiology. In this work, the effect of the dye on the RT/RR coupling measured in electrograms (EG) recorded on rabbit isolated hearts was studied. The results were compared with the control experiments without VSD administration. The comparison was performed in preparation stage of the experiment that consisted of three phases: stabilization (S), VSD loading (L), and washout (W). The median and interquartile range (Q0.75-Q0.25) of the difference in RR, QT and RT/RR between the beginning and the end of the phases were computed and compared between the both groups.(RT/RR), in S, L and W, was -0.095, 0.061; -0.093, 0.043; -0.027, 0.039 indi-4-ANEPPS-treated group and -0.127, 0.071; 0.006, 0.016; -0.001, 0.025 in control group. The significant difference (P&lt;0.01) was found between two groups in L phase. Additionally, there was the significant difference in RR [ms] which

Druh

D - Stať ve sborníku

CEP obor

ED - Fyziologie

OECD FORD obor

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Projekt

<a href="/cs/project/GAP102%2F12%2F2034" target="_blank" >GAP102/12/2034: Analýza vztahu mezi elektrickými ději a průtokem krve u srdečních komor</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Computing in Cardiology 2015

ISBN

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ISSN

2325-8861

e-ISSN

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Počet stran výsledku

4

Strana od-do

521-524

Název nakladatele

IEEE Computer Society

Místo vydání

Washington

Místo konání akce

Nice

Datum konání akce

1. 1. 2015

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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