Voltage Sensitive Dye di-4-ANNEPS Prolongs Impulse Conduction Through Ventricles, but not Through AV Node in Isolated Rabbit Heart

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F15%3APU116284" target="_blank" >RIV/00216305:26220/15:PU116284 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/15:00081269

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Voltage Sensitive Dye di-4-ANNEPS Prolongs Impulse Conduction Through Ventricles, but not Through AV Node in Isolated Rabbit Heart

Popis výsledku v původním jazyce

Voltage sensitive dyes are widely used for measurement of action potential in various cardiac studies. The elementary condition for its application is fact that measured electrophysiological parameters would not be affected by measuring procedure itself.The prolongation of RR interval in the presence of the most used voltage sensitive dye di-4-ANEPPS has been reported, however the exact mechanism is not known. In this study we examine impact of di-4-ANEPPS on impulse conduction through the atrioventricular (AV) node and cardiac ventricles in isolated rabbit heart. The impulse conduction through AV node in presence of di-4-ANEPPS was prolonged only in phase of dye loading at 14th, 16th and 17th minute. Only sporadic AV block was observed. In comparison, the prolongation of impulse conduction through cardiac ventricles was observed after 13th minute of dye loading and persisted to the end of this phase as well as over the whole wash out phase.

Název v anglickém jazyce

Voltage Sensitive Dye di-4-ANNEPS Prolongs Impulse Conduction Through Ventricles, but not Through AV Node in Isolated Rabbit Heart

Popis výsledku anglicky

Voltage sensitive dyes are widely used for measurement of action potential in various cardiac studies. The elementary condition for its application is fact that measured electrophysiological parameters would not be affected by measuring procedure itself.The prolongation of RR interval in the presence of the most used voltage sensitive dye di-4-ANEPPS has been reported, however the exact mechanism is not known. In this study we examine impact of di-4-ANEPPS on impulse conduction through the atrioventricular (AV) node and cardiac ventricles in isolated rabbit heart. The impulse conduction through AV node in presence of di-4-ANEPPS was prolonged only in phase of dye loading at 14th, 16th and 17th minute. Only sporadic AV block was observed. In comparison, the prolongation of impulse conduction through cardiac ventricles was observed after 13th minute of dye loading and persisted to the end of this phase as well as over the whole wash out phase.

Druh

D - Stať ve sborníku

CEP obor

JD - Využití počítačů, robotika a její aplikace

OECD FORD obor

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Projekt

<a href="/cs/project/GAP102%2F12%2F2034" target="_blank" >GAP102/12/2034: Analýza vztahu mezi elektrickými ději a průtokem krve u srdečních komor</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Computing in Cardiology 2015

ISBN

978-1-4799-4347-0

ISSN

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e-ISSN

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Počet stran výsledku

4

Strana od-do

1-4

Název nakladatele

Neuveden

Místo vydání

Nice, Francie

Místo konání akce

Nice, France

Datum konání akce

6. 9. 2015

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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