MicroRNAs in pulmonary arterial hypertension: pathogenesis, diagnosis and treatment

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F15%3A00083305" target="_blank" >RIV/00216224:14110/15:00083305 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.ashjournal.com/article/S1933-1711(14)00909-7/abstract" target="_blank" >http://www.ashjournal.com/article/S1933-1711(14)00909-7/abstract</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jash.2014.12.011" target="_blank" >10.1016/j.jash.2014.12.011</a>

Jazyk výsledku

angličtina

Název v původním jazyce

MicroRNAs in pulmonary arterial hypertension: pathogenesis, diagnosis and treatment

Popis výsledku v původním jazyce

Pulmonary arterial hypertension (PAH) is a severe and increasingly prevalent disease, manifested by the maladaptation of pulmonary vasculature, which consequently leads to right heart failure and possibly even death. The development of PAH is characterized by specific functional as well as structural changes, primarily associated with the aberrant function of the pulmonary artery endothelial cells, smooth muscle cells, and vascular fibroblasts. MicroRNAs constitute a class of small 22?nucleotides?long non?coding RNAs that post?transcriptionally regulate gene expression and that may lead to significant cell proteome changes. While the involvement of miRNAs in the development of various diseases?especially cancer?has been reported, numerous miRNAs have also been associated with PAH onset, progression, or treatment responsiveness.

Název v anglickém jazyce

MicroRNAs in pulmonary arterial hypertension: pathogenesis, diagnosis and treatment

Popis výsledku anglicky

Pulmonary arterial hypertension (PAH) is a severe and increasingly prevalent disease, manifested by the maladaptation of pulmonary vasculature, which consequently leads to right heart failure and possibly even death. The development of PAH is characterized by specific functional as well as structural changes, primarily associated with the aberrant function of the pulmonary artery endothelial cells, smooth muscle cells, and vascular fibroblasts. MicroRNAs constitute a class of small 22?nucleotides?long non?coding RNAs that post?transcriptionally regulate gene expression and that may lead to significant cell proteome changes. While the involvement of miRNAs in the development of various diseases?especially cancer?has been reported, numerous miRNAs have also been associated with PAH onset, progression, or treatment responsiveness.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of the American Society of Hypertension

ISSN

1933-1711

e-ISSN

—

Svazek periodika

9

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

14

Strana od-do

221-234

Kód UT WoS článku

000351809800008

EID výsledku v databázi Scopus

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