Glioblastoma Multiforme in a Patient with Isolated Hemimegalencephaly

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F15%3A00083712" target="_blank" >RIV/00216224:14110/15:00083712 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00159816:_____/15:00063576

Výsledek na webu

<a href="http://dx.doi.org/10.1055/s-0035-1554929" target="_blank" >http://dx.doi.org/10.1055/s-0035-1554929</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1055/s-0035-1554929" target="_blank" >10.1055/s-0035-1554929</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Glioblastoma Multiforme in a Patient with Isolated Hemimegalencephaly

Popis výsledku v původním jazyce

We present an exceptional case of a patient with hemimegalencephaly and secondary intractable epilepsy treated with vagus nerve stimulation (VNS) and subsequent glioblastoma development in the hemimegalencephalic hemisphere 6 years after surgery. VNS (atage 18 years) led to a 60% reduction of intractable seizures. However, symptoms of intracranial hypertension suddenly occurred 6 years after surgery. A computed tomography scan revealed a brain tumor in the hemimegalencephalic hemisphere. Pathologic examination confirmed glioblastoma multiforme. The genetic background of hemimegalencephaly is discussed here, with attention paid to the available data about the malignant transformation of malformations of cortical development (MCDs). The case points to the need for adequate clinical and radiologic follow-up care for patients with MCDs including hemimegalencephaly.

Název v anglickém jazyce

Glioblastoma Multiforme in a Patient with Isolated Hemimegalencephaly

Popis výsledku anglicky

We present an exceptional case of a patient with hemimegalencephaly and secondary intractable epilepsy treated with vagus nerve stimulation (VNS) and subsequent glioblastoma development in the hemimegalencephalic hemisphere 6 years after surgery. VNS (atage 18 years) led to a 60% reduction of intractable seizures. However, symptoms of intracranial hypertension suddenly occurred 6 years after surgery. A computed tomography scan revealed a brain tumor in the hemimegalencephalic hemisphere. Pathologic examination confirmed glioblastoma multiforme. The genetic background of hemimegalencephaly is discussed here, with attention paid to the available data about the malignant transformation of malformations of cortical development (MCDs). The case points to the need for adequate clinical and radiologic follow-up care for patients with MCDs including hemimegalencephaly.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Neurological Surgery Reports

ISSN

2193-6358

e-ISSN

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Svazek periodika

76

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

4

Strana od-do

"e160"-"e163"

Kód UT WoS článku

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EID výsledku v databázi Scopus

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