Alcohol Consumption at Midlife and Risk of Stroke During 43 Years of Follow-Up Cohort and Twin Analyses
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F15%3A00083804" target="_blank" >RIV/00216224:14110/15:00083804 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00159816:_____/15:00061566
Výsledek na webu
<a href="http://dx.doi.org/10.1161/STROKEAHA.114.006724" target="_blank" >http://dx.doi.org/10.1161/STROKEAHA.114.006724</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1161/STROKEAHA.114.006724" target="_blank" >10.1161/STROKEAHA.114.006724</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Alcohol Consumption at Midlife and Risk of Stroke During 43 Years of Follow-Up Cohort and Twin Analyses
Popis výsledku v původním jazyce
Background and Purpose-Although alcohol-stroke association is well known, the age-varying effect of alcohol drinking at midlife on subsequent stroke risk across older adulthood has not been examined. The effect of genetic/early-life factors is also unknown. We used cohort and twin analyses of data with 43 years of follow-up for stroke incidence to help address these gaps. Methods-All 11 644 members of the population-based Swedish Twin Registry born 1886 to 1925 with alcohol data aged <= 60 years wereincluded. The interaction of midlife alcohol consumption by age at stroke was evaluated in Coxregression and analyses of monozygotic twins were used. Covariates were baseline age, sex, cardiovascular diseases, diabetes mellitus, stress reactivity, depression, body mass index, smoking, and exercise. Results-Altogether 29% participants developed stroke. Compared with very-light drinkers (<0.5 drink/d), heavy drinkers (>2 drinks/d) had greater risk of stroke (hazard ratio, 1.34; P=0.
Název v anglickém jazyce
Alcohol Consumption at Midlife and Risk of Stroke During 43 Years of Follow-Up Cohort and Twin Analyses
Popis výsledku anglicky
Background and Purpose-Although alcohol-stroke association is well known, the age-varying effect of alcohol drinking at midlife on subsequent stroke risk across older adulthood has not been examined. The effect of genetic/early-life factors is also unknown. We used cohort and twin analyses of data with 43 years of follow-up for stroke incidence to help address these gaps. Methods-All 11 644 members of the population-based Swedish Twin Registry born 1886 to 1925 with alcohol data aged <= 60 years wereincluded. The interaction of midlife alcohol consumption by age at stroke was evaluated in Coxregression and analyses of monozygotic twins were used. Covariates were baseline age, sex, cardiovascular diseases, diabetes mellitus, stress reactivity, depression, body mass index, smoking, and exercise. Results-Altogether 29% participants developed stroke. Compared with very-light drinkers (<0.5 drink/d), heavy drinkers (>2 drinks/d) had greater risk of stroke (hazard ratio, 1.34; P=0.
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FH - Neurologie, neurochirurgie, neurovědy
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: Fakultní nemocnice u sv. Anny v Brně - Mezinárodní centrum klinického výzkumu (FNUSA - ICRC)</a><br>
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2015
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Stroke
ISSN
0039-2499
e-ISSN
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Svazek periodika
46
Číslo periodika v rámci svazku
3
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
7
Strana od-do
627-633
Kód UT WoS článku
000350284900017
EID výsledku v databázi Scopus
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