Antineoplastic effects of Chlorella pyrenoidosa in the breast cancer model

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F15%3A00085443" target="_blank" >RIV/00216224:14110/15:00085443 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00159816:_____/15:00063187

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.nut.2014.08.010" target="_blank" >http://dx.doi.org/10.1016/j.nut.2014.08.010</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.nut.2014.08.010" target="_blank" >10.1016/j.nut.2014.08.010</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Antineoplastic effects of Chlorella pyrenoidosa in the breast cancer model

Popis výsledku v původním jazyce

Objectives: There has been considerable interest in both clinical and preclinical research about the role of phytochemicals in the reduction of risk for cancer in humans. The aim of this study was to determine the antineoplastic effects of Chlorella pyrenoidosa in experimental breast cancer in vivo and in vitro. Methods: In this experiment, the antineoplastic effects of Chlorella pyrenoidosa in the chemoprevention of N-methyl-N-nitrosourea-induced mammary carcinogenesis in female rats were evaluated. Chlorella powder was administered through diet at concentrations of 0.3% and 3%. The experiment was terminated 14 wk after carcinogen administration. At autopsy, mammary tumors were removed and prepared for histopathological and immunohistochemical analysis. In vitro cytotoxicity assay, parameters of apoptosis, and proliferation after chlorella treatment in human breast adenocarcinoma (MCF-7) cells were carried out.

Název v anglickém jazyce

Antineoplastic effects of Chlorella pyrenoidosa in the breast cancer model

Popis výsledku anglicky

Objectives: There has been considerable interest in both clinical and preclinical research about the role of phytochemicals in the reduction of risk for cancer in humans. The aim of this study was to determine the antineoplastic effects of Chlorella pyrenoidosa in experimental breast cancer in vivo and in vitro. Methods: In this experiment, the antineoplastic effects of Chlorella pyrenoidosa in the chemoprevention of N-methyl-N-nitrosourea-induced mammary carcinogenesis in female rats were evaluated. Chlorella powder was administered through diet at concentrations of 0.3% and 3%. The experiment was terminated 14 wk after carcinogen administration. At autopsy, mammary tumors were removed and prepared for histopathological and immunohistochemical analysis. In vitro cytotoxicity assay, parameters of apoptosis, and proliferation after chlorella treatment in human breast adenocarcinoma (MCF-7) cells were carried out.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FM - Hygiena

OECD FORD obor

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Projekt

<a href="/cs/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: Fakultní nemocnice u sv. Anny v Brně - Mezinárodní centrum klinického výzkumu (FNUSA - ICRC)</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nutrition

ISSN

0899-9007

e-ISSN

—

Svazek periodika

31

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

560-569

Kód UT WoS článku

000351975200003

EID výsledku v databázi Scopus

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