Polymorphisms in Vitamin D Receptor Gene in Orthodontic Patients with External Apical Root Resorption

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F16%3A00088649" target="_blank" >RIV/00216224:14110/16:00088649 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00159816:_____/16:00066629

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Polymorphisms in Vitamin D Receptor Gene in Orthodontic Patients with External Apical Root Resorption

Popis výsledku v původním jazyce

AIMS: To investigate possible links between single nucleotid polymorphisms in vitamin D receptor gene and root resorption after orthodontic treatment. SUBJECTS AND METHOD: One hundred children were included in this study (31 patients aged 10 ± 4.1 years with external apical root resorption greater than 2 mm on panoramic radiographs after orthodontic treatment and 69 patients aged 12 ± 3 years without resorption). DNA was analyzed with real-time polymerase chain reaction for TaqI, BsmI, ApaI, FokI and Cdx2 polymorphisms. The obtained genotypes were evaluated in relation to gender, age, skeletal Class and the type of orthodontic treatment. RESULTS: No statistically significant differences were found between patients with and without resorption concerning occurrence of alleles or genotypes for each polymorphism. In a more detailed analysis, marginally important differences (trends) were observed for the frequencies of ApaI (P = 0.059) and the haplotype TGCTA (P = 0.063) in boys.

Název v anglickém jazyce

Polymorphisms in Vitamin D Receptor Gene in Orthodontic Patients with External Apical Root Resorption

Popis výsledku anglicky

AIMS: To investigate possible links between single nucleotid polymorphisms in vitamin D receptor gene and root resorption after orthodontic treatment. SUBJECTS AND METHOD: One hundred children were included in this study (31 patients aged 10 ± 4.1 years with external apical root resorption greater than 2 mm on panoramic radiographs after orthodontic treatment and 69 patients aged 12 ± 3 years without resorption). DNA was analyzed with real-time polymerase chain reaction for TaqI, BsmI, ApaI, FokI and Cdx2 polymorphisms. The obtained genotypes were evaluated in relation to gender, age, skeletal Class and the type of orthodontic treatment. RESULTS: No statistically significant differences were found between patients with and without resorption concerning occurrence of alleles or genotypes for each polymorphism. In a more detailed analysis, marginally important differences (trends) were observed for the frequencies of ApaI (P = 0.059) and the haplotype TGCTA (P = 0.063) in boys.

Druh

O - Ostatní výsledky

CEP obor

FF - ORL, oftalmologie, stomatologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů