IL1 gene polymorphisms in relation to external apical root resorption concurrent with orthodontia

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F13%3A00060633" target="_blank" >RIV/00159816:_____/13:00060633 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/13:00065565

Výsledek na webu

<a href="http://dx.doi.org/10.1111/j.1601-0825.2012.01973.x" target="_blank" >http://dx.doi.org/10.1111/j.1601-0825.2012.01973.x</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/j.1601-0825.2012.01973.x" target="_blank" >10.1111/j.1601-0825.2012.01973.x</a>

Jazyk výsledku

angličtina

Název v původním jazyce

IL1 gene polymorphisms in relation to external apical root resorption concurrent with orthodontia

Popis výsledku v původním jazyce

OBJECTIVE: External apical root resorption (EARR) is permanent shortening of the end of the tooth root. It is a common clinical complication of orthodontic treatment. Polymorphisms in the interleukin 1 (IL1) gene cluster have been related to an increasedEARR risk. The aim of this study was to analyze possible associations of IL1 gene variants with EARR in Czech population. SUBJECTS AND METHODS: In this case-control study, 32 patients with EARR (age 15.0 +/- 4.1 years) and 74 controls (age 15.2 +/- 5.3years) were genotyped using PCR-based methods for IL1A (-889C/T), IL1B (+3953C/T), and IL1RN [IL1 receptor antagonist, variable number tandem repeat (VNTR)] gene polymorphisms. RESULTS: While no statistical significant differences in the IL1A and IL1B genotype, allele and reconstructed IL1 haplotype frequencies between patients with EARR and controls were found, marginally significant differences were observed in the frequencies of IL1RN variant (P = 0.05 for *22 genotype and P = 0.06 fo

Název v anglickém jazyce

IL1 gene polymorphisms in relation to external apical root resorption concurrent with orthodontia

Popis výsledku anglicky

OBJECTIVE: External apical root resorption (EARR) is permanent shortening of the end of the tooth root. It is a common clinical complication of orthodontic treatment. Polymorphisms in the interleukin 1 (IL1) gene cluster have been related to an increasedEARR risk. The aim of this study was to analyze possible associations of IL1 gene variants with EARR in Czech population. SUBJECTS AND METHODS: In this case-control study, 32 patients with EARR (age 15.0 +/- 4.1 years) and 74 controls (age 15.2 +/- 5.3years) were genotyped using PCR-based methods for IL1A (-889C/T), IL1B (+3953C/T), and IL1RN [IL1 receptor antagonist, variable number tandem repeat (VNTR)] gene polymorphisms. RESULTS: While no statistical significant differences in the IL1A and IL1B genotype, allele and reconstructed IL1 haplotype frequencies between patients with EARR and controls were found, marginally significant differences were observed in the frequencies of IL1RN variant (P = 0.05 for *22 genotype and P = 0.06 fo

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FF - ORL, oftalmologie, stomatologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Oral diseases

ISSN

1354-523X

e-ISSN

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Svazek periodika

19

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

262-270

Kód UT WoS článku

000317490300005

EID výsledku v databázi Scopus

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