Polymorphisms in genes encoding purinoreceptor and osteoprotegerin and external apical root resorption in children after orthodontic treatment
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F16%3A00088272" target="_blank" >RIV/00216224:14110/16:00088272 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00159816:_____/16:00066193
Výsledek na webu
<a href="http://dx.doi.org/10.4172/2161-1122.C1.006" target="_blank" >http://dx.doi.org/10.4172/2161-1122.C1.006</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4172/2161-1122.C1.006" target="_blank" >10.4172/2161-1122.C1.006</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Polymorphisms in genes encoding purinoreceptor and osteoprotegerin and external apical root resorption in children after orthodontic treatment
Popis výsledku v původním jazyce
Orthodontically induced external apical root resoption (EARR) is a multifactorial inflammatory disease. Genes encoding proteins, which are involved in the modulation of inflammatory response and bone remodeling, are considered as the “candidate” for EARR. The aim of this study was to analyze possible associations of single nucleotide polymorphisms (SNPs) in the P2RX7 (encoding purinoreceptor) and TNFRSF11B (encoding osteoprotegerin) genes with EARR in Czech children after orthodontic treatment. A total, 99 orthodontically treated patients (69 healthy and 30 with EARR) were enrolled in this case-control study. Genotype determination of P2RX7 +489C/T (rs208294, Tyr155His) and +1068C/T (rs1718119, Thr348Ala), TNFRSF11B -163C/T (rs3102735) and TNFRSF11B +1181C/G (rs2073618, Lys3Asn) was based on polymerase chain reaction using 5 nuclease TaqMan® assays.
Název v anglickém jazyce
Polymorphisms in genes encoding purinoreceptor and osteoprotegerin and external apical root resorption in children after orthodontic treatment
Popis výsledku anglicky
Orthodontically induced external apical root resoption (EARR) is a multifactorial inflammatory disease. Genes encoding proteins, which are involved in the modulation of inflammatory response and bone remodeling, are considered as the “candidate” for EARR. The aim of this study was to analyze possible associations of single nucleotide polymorphisms (SNPs) in the P2RX7 (encoding purinoreceptor) and TNFRSF11B (encoding osteoprotegerin) genes with EARR in Czech children after orthodontic treatment. A total, 99 orthodontically treated patients (69 healthy and 30 with EARR) were enrolled in this case-control study. Genotype determination of P2RX7 +489C/T (rs208294, Tyr155His) and +1068C/T (rs1718119, Thr348Ala), TNFRSF11B -163C/T (rs3102735) and TNFRSF11B +1181C/G (rs2073618, Lys3Asn) was based on polymerase chain reaction using 5 nuclease TaqMan® assays.
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
EB - Genetika a molekulární biologie
OECD FORD obor
—
Návaznosti výsledku
Projekt
<a href="/cs/project/GB14-37368G" target="_blank" >GB14-37368G: Centrum orofaciálního vývoje a regenerace</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2016
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů