The Effect of Cardiac Filling on Heart Rate Variability in Rabbit Isolated Heart

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F17%3A00094616" target="_blank" >RIV/00216224:14110/17:00094616 - isvavai.cz</a>

Výsledek na webu

<a href="http://ieeexplore.ieee.org/document/7868789/" target="_blank" >http://ieeexplore.ieee.org/document/7868789/</a>

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

The Effect of Cardiac Filling on Heart Rate Variability in Rabbit Isolated Heart

Popis výsledku v původním jazyce

Presence of heart rate variability (HRV) in isolated hearts is widely recognized; however, its mechanisms are still subject of debate. One of the possible explanations is that mechanoreceptors in cardiac tissue affect HRV. In order to evaluate possible dependence of HRV on heart mechanoreceptors activated during left ventricle filling, the HRV parameters in two perfusion modes of isolated heart were compared: Langendorff and working heart mode. Ten New Zealand rabbit isolated hearts were perfused (Krebs-Henseleit, 37°C, 85 mmHg) in Langendorff mode and consecutively in working heart mode (8 cmH2O preload, 60 cmfyO afterload). A total of 27 HRV parameters in time, frequency, geometric, and non-linear domain were computed. No significant differences (Wilcoxon signed rank test, p &lt; 0.05) were found among all studied HRV parameters between Langendorff and working heart mode. The study confirms the presence of heart rate fluctuation in isolated hearts in both Langendorff and working heart modes. Results of statistical analysis show that heart rate fluctuation is irrespective to mechanical stimulation of heart during atrium and ventricle filling.

Název v anglickém jazyce

The Effect of Cardiac Filling on Heart Rate Variability in Rabbit Isolated Heart

Popis výsledku anglicky

Presence of heart rate variability (HRV) in isolated hearts is widely recognized; however, its mechanisms are still subject of debate. One of the possible explanations is that mechanoreceptors in cardiac tissue affect HRV. In order to evaluate possible dependence of HRV on heart mechanoreceptors activated during left ventricle filling, the HRV parameters in two perfusion modes of isolated heart were compared: Langendorff and working heart mode. Ten New Zealand rabbit isolated hearts were perfused (Krebs-Henseleit, 37°C, 85 mmHg) in Langendorff mode and consecutively in working heart mode (8 cmH2O preload, 60 cmfyO afterload). A total of 27 HRV parameters in time, frequency, geometric, and non-linear domain were computed. No significant differences (Wilcoxon signed rank test, p &lt; 0.05) were found among all studied HRV parameters between Langendorff and working heart mode. The study confirms the presence of heart rate fluctuation in isolated hearts in both Langendorff and working heart modes. Results of statistical analysis show that heart rate fluctuation is irrespective to mechanical stimulation of heart during atrium and ventricle filling.

Druh

D - Stať ve sborníku

CEP obor

—

OECD FORD obor

30105 - Physiology (including cytology)

Projekt

<a href="/cs/project/GAP102%2F12%2F2034" target="_blank" >GAP102/12/2034: Analýza vztahu mezi elektrickými ději a průtokem krve u srdečních komor</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Computing in Cardiology 2016

ISBN

9781509008964

ISSN

2325-8861

e-ISSN

—

Počet stran výsledku

4

Strana od-do

501-504

Název nakladatele

IEEE Computer Society

Místo vydání

Washington

Místo konání akce

Vancouver

Datum konání akce

1. 1. 2016

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

—