The Effect of Haloperidol Administration on Heart Rate Variability in Isolated Heart of Schizophrenia-like and Control Rats

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F17%3APU125221" target="_blank" >RIV/00216305:26220/17:PU125221 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.22489/CinC.2017.150-161" target="_blank" >http://dx.doi.org/10.22489/CinC.2017.150-161</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.22489/CinC.2017.150-161" target="_blank" >10.22489/CinC.2017.150-161</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The Effect of Haloperidol Administration on Heart Rate Variability in Isolated Heart of Schizophrenia-like and Control Rats

Popis výsledku v původním jazyce

Deeper understanding of heart rate variability (HRV) changes induced by haloperidol administration can contribute to overcoming of adverse cardiovascular effects of antipsychotics. The effect of haloperidol administration on HRV was therefore studied in nine schizophrenia-like rat isolated hearts and six control rat hearts. Isolated hearts were stabilized (20 min) on Langendorff perfusion system, then exposed to haloperidol (40 min) and finally washed out (40 min). The effect of haloperidol administration was studied in tachograms obtained from touchless-recorded electrograms (5 kHz, 12-bit). HRV parameters evolution in time, frequency, geometric, and non-linear domain were computed from 10 minutes long tachogram segments during stabilization, haloperidol exposition and washout periods. The haloperidol administration significantly affected HRV parameters in control rat hearts, but it had limited effect on schizophrenia-like ones. The effect of haloperidol administration was irreversible, since the washout did not restore HRV parameters to their initial values.

Název v anglickém jazyce

The Effect of Haloperidol Administration on Heart Rate Variability in Isolated Heart of Schizophrenia-like and Control Rats

Popis výsledku anglicky

Deeper understanding of heart rate variability (HRV) changes induced by haloperidol administration can contribute to overcoming of adverse cardiovascular effects of antipsychotics. The effect of haloperidol administration on HRV was therefore studied in nine schizophrenia-like rat isolated hearts and six control rat hearts. Isolated hearts were stabilized (20 min) on Langendorff perfusion system, then exposed to haloperidol (40 min) and finally washed out (40 min). The effect of haloperidol administration was studied in tachograms obtained from touchless-recorded electrograms (5 kHz, 12-bit). HRV parameters evolution in time, frequency, geometric, and non-linear domain were computed from 10 minutes long tachogram segments during stabilization, haloperidol exposition and washout periods. The haloperidol administration significantly affected HRV parameters in control rat hearts, but it had limited effect on schizophrenia-like ones. The effect of haloperidol administration was irreversible, since the washout did not restore HRV parameters to their initial values.

Druh

D - Stať ve sborníku

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

<a href="/cs/project/GAP102%2F12%2F2034" target="_blank" >GAP102/12/2034: Analýza vztahu mezi elektrickými ději a průtokem krve u srdečních komor</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Computing in Cardiology, 2017

ISBN

978-1-5090-0684-7

ISSN

0276-6574

e-ISSN

—

Počet stran výsledku

4

Strana od-do

1-4

Název nakladatele

Computing in Cardiology 2017

Místo vydání

Rennes, France

Místo konání akce

Rennes

Datum konání akce

24. 9. 2017

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

000450651100129